Table 3 Associations between SORL1 rs1784933 and plasma amyloid-beta concentration
Multivariate regression model | Aβ42 | Aβ40 | Aβ42/Aβ40 ratio | |
|---|---|---|---|---|
AD (n = 592) | 23.8 ± 15.1 | 173.1 ± 79.3 | 0.15 ± 0.25 | |
MCI (n = 119) | 23.6 ± 12.5 | 178.7 ± 54.6 | 0.14 ± 0.07 | |
Control subjects (n = 170) | 23.7 ± 12.6 | 171.6 ± 64.3 | 0.15 ± 0.08 | |
AD vs. control subjects | p = 0.899 | p = 0.807 | p = 0.904 | |
MCI vs. control subjects | p = 0.969 | p = 0.318 | p = 0.189 | |
SORL1 rs1784933 in overall participants (n = 873) | ||||
G allele carriers (AG + GG genotypes) | 22.68 ± 13.82 | 168.51 ± 65.93 | 0.14 ± 0.08 | |
G allele noncarriers (AA genotype) | 24.82 ± 14.67 | 178.33 ± 79.81 | 0.16 ± 0.27 | |
G allele carriers vs. noncarriers | ||||
Raw p value | p = 0.026 | p = 0.048 | p = 0.214 | |
Adjusted for age and sex | Adj p = 0.029 | Adj p = 0.054 | Adj p = 0.217 | |
Adjusted for age, sex, and APOE ε4 allele | Adj p = 0.046 | Adj p = 0.071 | Adj p = 0.248 | |
SORL1 rs1784933 in patients with AD (n = 584) | ||||
G allele carriers (AG + GG genotypes) | 22.62 ± 14.48 | 168.86 ± 70.79 | 0.14 ± 0.08 | |
G allele noncarriers (AA genotype) | 25.00 ± 15.60 | 177.14 ± 86.24 | 0.16 ± 0.33 | |
G allele carriers vs. noncarriers | ||||
Raw p value | p = 0.056 | p = 0.205 | p = 0.203 | |
Adjusted for age and sex | Adj p = 0.056 | Adj p = 0.204 | Adj p = 0.203 | |
Adjusted for age, sex, and APOE ε4 allele | Adj p = 0.058 | Adj p = 0.211 | Adj p = 0.206 | |