Table 2 Genotype distribution of SORL1 single-nucleotide polymorphisms among patients with Alzheimer’s disease, patients with mild cognitive impairment, and control subjects
MM/Mm/mm, n (%) | Multivariate regression analysis | ||||||
|---|---|---|---|---|---|---|---|
SNP | Allele (M/m) | Control subjects | MCI | AD | MCI vs. control subjects | AD vs. control subjects | AD + MCI vs. control subjects |
rs2298813 (SNP13) | G/A | 291/90/9 (74.6/23.1/2.3) | 134/18/2 (87.0/11.7/1.3) | 597/176/12 (76.1/22.4/1.5) | OR = 0.49, p = 0.003 | OR = 0.91, p = 0.455 | OR = 0.84, p = 0.154 |
Adj OR = 0.49, p = 0.003 | Adj OR = 0.82, p = 0.156 | Adj OR = 0.76, p = 0.035 | |||||
rs2070045 (SNP19) | G/T | 144/186/64 (36.5/47.2/16.2) | 54/77/25 (34.6/49.4/16.0) | 302/392/99 (38.1/49.4/12.5) | OR = 1.04, p = 0.794 | OR = 0.89, p = 0.204 | OR = 0.91, p = 0.307 |
Adj OR = 1.02, p = 0.909 | Adj OR = 0.87, p = 0.149 | Adj OR = 0.90, p = 0.256 | |||||
rs1699102 (SNP22) | C/T | 330/61/1 (84.2/15.6/0.3) | 129/28/0 (82.2/17.8/0.0) | 666/123/7 (83.7/15.5/0.9) | OR = 1.13, p = 0.620 | OR = 1.08, p = 0.637 | OR = 1.09, p = 0.596 |
Adj OR = 1.13, p = 0.633 | Adj OR = 1.06, p = 0.711 | Adj OR = 1.07, p = 0.687 | |||||
rs3824968 (SNP23) | A/T | 155/184/56 (39.2/46.6/14.2) | 61/76/19 (39.1/48.7/12.2) | 313/390/88 (39.6/49.3/11.1) | OR = 0.96, p = 0.772 | OR = 0.93, p = 0.409 | OR = 0.93, p = 0.431 |
Adj OR = 0.95, p = 0.710 | Adj OR = 0.90, p = 0.300 | Adj OR = 0.92, p = 0.375 | |||||
rs3737529 | C/T | 239/142/20 (59.6/35.4/5.0) | 103/50/4 (65.6/31.8/2.5) | 508/257/33 (63.7/32.2/4.1) | OR = 0.77, p = 0.120 | OR = 0.86, p = 0.164 | OR = 0.85, p = 0.107 |
Adj OR = 0.78, p = 0.140 | Adj OR = 0.82, p = 0.073 | Adj OR = 0.82, p = 0.069 | |||||
rs2282649 (SNP24) | T/C | 148/188/56 (37.8/48.0/14.3) | 59/79/18 (37.8/50.6/11.5) | 305/391/93 (38.7/49.6/11.8) | OR = 0.94, p = 0.659 | OR = 0.93, p = 0.409 | OR = 0.93, p = 0.408 |
Adj OR = 0.92, p = 0.585 | Adj OR = 0.90, p = 0.297 | Adj OR = 0.92, p = 0.356 | |||||
rs1010159 (SNP25) | C/T | 155/181/55 (39.6/46.3/14.1) | 62/77/18 (39.5/49.0/11.5) | 315/386/89 (39.9/48.9/11.3) | OR = 0.95, p = 0.702 | OR = 0.93, p = 0.462 | OR = 0.94, p = 0.463 |
Adj OR = 0.93, p = 0.598 | Adj OR = 0.91, p = 0.322 | Adj OR = 0.92, p = 0.380 | |||||
rs1784933 (SNP26) | A/G | 178/175/47 (44.5/43.8/11.8) | 86/61/10 (54.8/38.9/6.4) | 408/326/63 (51.2/40.9/7.9) | OR = 0.69, p = 0.012 | OR = 0.78, p = 0.008 | OR = 0.77, p = 0.003 |
Adj OR = 0.69, p = 0.013 | Adj OR = 0.75, p = 0.004 | Adj OR = 0.74, p = 0.002 | |||||