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Table 2 Estimates of variables in Cox regression

From: Conflicting cerebrospinal fluid biomarkers and progression to dementia due to Alzheimer’s disease

Variable

Regression coefficient (b)

p value

Estimated hazard

95% confidence interval for hazard ratio

MCI subgroups

 

<0.001

  

 0 = MCINon+*

0.992

0.009

2.697

1.279–5.686

 1 = MCIAβ+

 0 = MCINon+*

1.060

0.001

2.887

1.538–5.422

 1 = MCIAβ+T+

 0 = MCINon+*

1.481

<0.001

4.399

2.417–8.006

 1 = MCIAll+

 0 = MCINon+*

0.591

0.185

1.806

0.753–4.330

 1 = MCIT+

 0 = MCIAβ+*

0.068

0.828

1.071

0.578–1.983

 1 = MCIAβ+T+

 0 = MCIAβ+*

0.489

0.105

1.631

0.903–2.945

 1 = MCIAll+

 0 = MCIAβ+*

–0.401

0.369

0.670

0.279–1.606

 1 = MCIT+

 0 = MCIAβ+T+*

0.421

0.029

1.524

1.045–2.222

 1 = MCIAll+

 0 = MCIAβ+T+*

–0.469

0.234

0.625

0.289–1.355

 1 = MCIT+

 0 = MCIAll+*

–0.890

0.02

0.410

0.194–0.870

 1 = MCIT+

Age

0.007

0.536

1.007

0.985–1.030

Sex

0.021

0.905

1.021

0.727 – 1.434

 0 = female*

 1 = male

MMSE

–0.215

<0.001

0.807

0.738 – 0.882

APOE ε4

–0.331

0.072

0.718

0.501 – 1.030

 0 = ε4 carriers*

 1 = ε4 non-carriers

  1. *Reference category
  2. MCI mild cognitive impairment, MCI Non+ MCI without positive cerebrospinal fluid (CSF) biomarkers, MCI Aβ+ MCI with positive amyloid-beta 1-42 (Aβ42) and negative or borderline tau phosphorylated at threonine 181 (p-Tau) and total tau (t-Tau), MCI Aβ+T+ MCI with positive Aβ42 and positive t-Tau or p-Tau, MCI All+ MCI with Aβ42 and both t-Tau and p-Tau positive, MCI T+ MCI with negative or borderline Aβ42 and at least p-Tau or t-Tau positive, MMSE Mini-Mental State Examination; APOE apolipoprotein E