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Table 2 Estimates of variables in Cox regression

From: Conflicting cerebrospinal fluid biomarkers and progression to dementia due to Alzheimer’s disease

Variable Regression coefficient (b) p value Estimated hazard 95% confidence interval for hazard ratio
MCI subgroups   <0.001   
 0 = MCINon+* 0.992 0.009 2.697 1.279–5.686
 1 = MCIAβ+
 0 = MCINon+* 1.060 0.001 2.887 1.538–5.422
 1 = MCIAβ+T+
 0 = MCINon+* 1.481 <0.001 4.399 2.417–8.006
 1 = MCIAll+
 0 = MCINon+* 0.591 0.185 1.806 0.753–4.330
 1 = MCIT+
 0 = MCIAβ+* 0.068 0.828 1.071 0.578–1.983
 1 = MCIAβ+T+
 0 = MCIAβ+* 0.489 0.105 1.631 0.903–2.945
 1 = MCIAll+
 0 = MCIAβ+* –0.401 0.369 0.670 0.279–1.606
 1 = MCIT+
 0 = MCIAβ+T+* 0.421 0.029 1.524 1.045–2.222
 1 = MCIAll+
 0 = MCIAβ+T+* –0.469 0.234 0.625 0.289–1.355
 1 = MCIT+
 0 = MCIAll+* –0.890 0.02 0.410 0.194–0.870
 1 = MCIT+
Age 0.007 0.536 1.007 0.985–1.030
Sex 0.021 0.905 1.021 0.727 – 1.434
 0 = female*
 1 = male
MMSE –0.215 <0.001 0.807 0.738 – 0.882
APOE ε4 –0.331 0.072 0.718 0.501 – 1.030
 0 = ε4 carriers*
 1 = ε4 non-carriers
  1. *Reference category
  2. MCI mild cognitive impairment, MCI Non+ MCI without positive cerebrospinal fluid (CSF) biomarkers, MCI Aβ+ MCI with positive amyloid-beta 1-42 (Aβ42) and negative or borderline tau phosphorylated at threonine 181 (p-Tau) and total tau (t-Tau), MCI Aβ+T+ MCI with positive Aβ42 and positive t-Tau or p-Tau, MCI All+ MCI with Aβ42 and both t-Tau and p-Tau positive, MCI T+ MCI with negative or borderline Aβ42 and at least p-Tau or t-Tau positive, MMSE Mini-Mental State Examination; APOE apolipoprotein E