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Table 1 Characteristics of the study sample

From: Conflicting cerebrospinal fluid biomarkers and progression to dementia due to Alzheimer’s disease

 

MCI subgroup

p value

MCINon+

MCIAβ+

MCIAβ+T+

MCIAll+

MCIT+

N

111

45

119

145

49

 

Age (years)

71.29 (7.83)

74.78 (6.59)

74.25 (7.06)

72.68 (7.40)

71.57 (9.00)

0.010

Education (years)

16.54 (2.70)

16.29 (3.07)

16.13 (2.77)

15.97 (2.83)

15.92 (2.86)

0.468

MMSE

28.13 (1.70)

27.64 (1.79)

27.42 (1.88)

26.93 (1.87)

27.92 (1.78)

<0.001

Sex (male:female)

67:44

34:11

78:41

73:72

29:20

0.020

APOE ε4 carriers (%)

21.62

42.22

62.18

77.93

26.53

<.001

CSF Aβ42 (pg/ml)

232.59 (30.25)

140.81 (26.14)

132.81 (23.70)

134.98 (20.96)

232.93 (30.24)

<0.001

CSF Aβ42 negative/borderline/positive for AD

87/24/0

0/0/45

0/0/119

0/0/145

39/10/0

<0.001

CSF p-Tau (pg/ml)

18.63 (4.44)

20.36 (4.45)

43.66 (16.00)

58.41 (2.53)

41.77 (13.58)

<0.001

CSF p-Tau negative/borderline/positive for AD

57/54/0

18/27/0

0/2/117

0/0/145

0/0/49

<0.001

CSF t-Tau (pg/ml)

50.66 (18.12)

55.53 (17.28)

78.37 (18.06)

158.09 (46.47)

74.86 (34.40)

<0.001

CSF t-Tau negative/borderline/positive for AD

106/5/0

42/3/0

59/58/2

0/0/145

29/15/5

<0.001

Follow-up period (months)

32.22 (23.34)

32.53 (23.50)

30.81 (22.34)

29.96 (21.01)

32.02 (11.64)

0.350

Dementia due to AD vs no dementia at follow-up

14:97

14:31

43:76

80:65

8:41

<0.001

  1. Data presented as mean (standard deviation) or frequencies
  2. AD Alzheimer’s disease, MCI mild cognitive impairment, APOE apolipoprotein E, MMSE Mini-Mental State Examination, CSF cerebrospinal fluid, Aβ42 amyloid-beta 1–42, p-Tau tau phosphorylated at threonine 181, t-Tau total tau, MCI Non+ MCI without positive CSF biomarkers, MCI Aβ+ MCI with positive Aβ42 and negative or borderline p-Tau and t-Tau, MCI Aβ+T+ MCI with positive Aβ42 and positive t-Tau or p-Tau, MCI All+ MCI with Aβ42 and both t-Tau and p-Tau positive, MCI T+ MCI with negative or borderline Aβ42 and at least p-Tau or t-Tau positive