Skip to main content
Fig. 2 | Alzheimer's Research & Therapy

Fig. 2

From: Angiotensin-converting enzyme 2 is reduced in Alzheimer’s disease in association with increasing amyloid-β and tau pathology

Fig. 2

Angiotensin-converting enzyme 2 (ACE-2) activity is reduced in association with apolipoprotein E (APOE) ε4 and ACE1 (rs1799752) indel polymorphism and increased in cerebral amyloid angiopathy (CAA). a Bar chart showing reduced ACE-2 activity in individuals with an APOE ε4 allele (P < 0.05). b Bar chart showing that ACE-2 activity varied according to ACE1 indel polymorphism (P < 0.05), with a trend towards reduced ACE-2 activity in ACE-1 II homozygotes. c Bar chart showing elevated ACE-2 activity in moderate to severe CAA compared with absent to mild CAA, approaching significance (P = 0.08). The bars indicate the mean value and SEM. *P < 0.05. rfu Relative fluorescence units

Back to article page

Alzheimer's Research & Therapy

ISSN: 1758-9193