Memantine | No memantine | Placebo | |||
---|---|---|---|---|---|
Placebo | Galantamine | Placebo | Galantamine | Memantine vs no memantine | |
Time to death | |||||
n/J (%) | 15/245 (6.1) | 19/251 (7.6) | 41/776 (5.3) | 14/773 (1.8) | |
Death rate (per 100 patient-years) | 4.49 | 5.57 | 4.15 | 1.39 | |
Hazard ratio (95 % CI) | 1.25 (0.63; 2.46) | 0.33 (0.18; 0.61) | 1.16 (0.65; 2.06) | ||
MMSE over time (change from baseline) | |||||
6 months | |||||
n | 215 | 202 | 673 | 671 | |
Mean (SD) | –0.49 (3.41) | –0.25 (3.01) | –0.22 (2.77) | 0.27 (2.63) | |
Effect size (95 % CI) | 0.07 (–0.12; 0.27) | 0.18 (0.07; 0.29) | p = 0.2410 | ||
12 months | |||||
n | 215 | 202 | 676 | 672 | |
Mean (SD) | –1.09 (3.84) | –1.09 (3.54) | –1.09 (3.45) | –0.34 (3.16) | |
Effect size (95 % CI) | 0.0 (–0.19; 0.19) | 0.23 (0.12; 0.33) | p = 1.00 | ||
18 months | |||||
n | 215 | 202 | 676 | 672 | |
Mean (SD) | –1.8 (3.89) | –1.86 (4.24) | –1.73 (4.03) | –0.84 (3.64) | |
Effect size (95 % CI) | –0.01 (–0.21; 0.18) | 0.23 (0.12; 0.34) | p = 0.8231 | ||
24 months | |||||
n | 215 | 202 | 676 | 672 | |
Mean (SD) | –2.10 (4.14) | –2.35 (4.48) | –2.15 (4.41) | –1.12 (3.87) | |
Effect size (95 % CI) | –0.06 (–0.25; 0.13) | 0.25 (0.14; 0.36) | p = 0.8832 | ||
DAD over time (change from baseline) | |||||
12 months | |||||
n | 201 | 182 | 620 | 628 | |
Mean (SD) | –7.70 (18.34) | –6.58 (18.59) | –6.10 (15.38) | –3.94 (13.29) | |
Effect size (95 % CI) | 0.06 (–0.14; 0.26) | 0.15 (0.04; 0.26) | p = 0.2227 | ||
24 months | |||||
n | 202 | 182 | 620 | 628 | |
Mean (SD) | –13.33 (20.79) | –11.78 (20.76) | –9.99 (17.31) | –7.11 (15.96) | |
Effect size (95 % CI) | 0.07 (–0.13; 0.28) | 0.17 (0.06; 0.28) | p = 0.0237 | ||
New nursing home placement (change from baseline (for 12 months) or from 12 months (for 24 months)) | |||||
12 months | |||||
n | 100 | 81 | 252 | 249 | |
Number (%) | 3 (3) | 9 (11.1) | 4 (1.6) | 3 (1.2) | |
Relative risk (95 % CI) | 3.70 (1.04; 13.23) | 0.76 (0.17; 3.36) | |||
χ2, p value | 4.76, p = 0.0292 | 0.13, p = 0.7153 | |||
24 months | |||||
n | 48 | 52 | 149 | 161 | |
Number (%) | 1 (2) | 4 (7.7) | 5 (3.4) | 1 (0.6) | |
Relative risk (95 % CI) | 3.70 (0.43; 31.89) | 0.19 (0.02; 1.57) | |||
χ2, p value | 1.65, p = 0.1985 | 3.05, p = 0.0808 | |||
New nursing home placement at 24 months (%) | 5 | 18.8 | 5 | 1.8 |