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Table 2 Mortality, cognitive, functional, and disposition outcome measures

From: Effect of concomitant use of memantine on mortality and efficacy outcomes of galantamine-treated patients with Alzheimer’s disease: post-hoc analysis of a randomized placebo-controlled study

 

Memantine

No memantine

Placebo

Placebo

Galantamine

Placebo

Galantamine

Memantine vs no memantine

Time to death

n/J (%)

15/245 (6.1)

19/251 (7.6)

41/776 (5.3)

14/773 (1.8)

 

 Death rate (per 100 patient-years)

4.49

5.57

4.15

1.39

 

 Hazard ratio (95 % CI)

1.25 (0.63; 2.46)

0.33 (0.18; 0.61)

1.16 (0.65; 2.06)

MMSE over time (change from baseline)

 6 months

   n

215

202

673

671

 

  Mean (SD)

–0.49 (3.41)

–0.25 (3.01)

–0.22 (2.77)

0.27 (2.63)

 

  Effect size (95 % CI)

0.07 (–0.12; 0.27)

0.18 (0.07; 0.29)

p = 0.2410

 12 months

   n

215

202

676

672

 

  Mean (SD)

–1.09 (3.84)

–1.09 (3.54)

–1.09 (3.45)

–0.34 (3.16)

 

  Effect size (95 % CI)

0.0 (–0.19; 0.19)

0.23 (0.12; 0.33)

p = 1.00

 18 months

   n

215

202

676

672

 

  Mean (SD)

–1.8 (3.89)

–1.86 (4.24)

–1.73 (4.03)

–0.84 (3.64)

 

  Effect size (95 % CI)

–0.01 (–0.21; 0.18)

 

0.23 (0.12; 0.34)

 

p = 0.8231

 24 months

   n

215

202

676

672

 

  Mean (SD)

–2.10 (4.14)

–2.35 (4.48)

–2.15 (4.41)

–1.12 (3.87)

 

  Effect size (95 % CI)

–0.06 (–0.25; 0.13)

 

0.25 (0.14; 0.36)

 

p = 0.8832

DAD over time (change from baseline)

 12 months

   n

201

182

620

628

 

  Mean (SD)

–7.70 (18.34)

–6.58 (18.59)

–6.10 (15.38)

–3.94 (13.29)

 

  Effect size (95 % CI)

0.06 (–0.14; 0.26)

 

0.15 (0.04; 0.26)

 

p = 0.2227

 24 months

   n

202

182

620

628

 

  Mean (SD)

–13.33 (20.79)

–11.78 (20.76)

–9.99 (17.31)

–7.11 (15.96)

 

  Effect size (95 % CI)

0.07 (–0.13; 0.28)

 

0.17 (0.06; 0.28)

 

p = 0.0237

New nursing home placement (change from baseline (for 12 months) or from 12 months (for 24 months))

 12 months

   n

100

81

252

249

 

  Number (%)

3 (3)

9 (11.1)

4 (1.6)

3 (1.2)

 

  Relative risk (95 % CI)

3.70 (1.04; 13.23)

0.76 (0.17; 3.36)

 

  χ2, p value

4.76, p = 0.0292

 

0.13, p = 0.7153

  

 24 months

   n

48

52

149

161

 

  Number (%)

1 (2)

4 (7.7)

5 (3.4)

1 (0.6)

 

  Relative risk (95 % CI)

3.70 (0.43; 31.89)

0.19 (0.02; 1.57)

 

  χ2, p value

1.65, p = 0.1985

3.05, p = 0.0808

 

New nursing home placement at 24 months (%)

5

18.8

5

1.8

 
  1. DAD Disability Assessment for Dementia, MMSE Mini-Mental State Examination, SD standard deviation
  2. n = the number of death cases; J = the number of subjects in each subgroup