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Table 2 Mortality, cognitive, functional, and disposition outcome measures

From: Effect of concomitant use of memantine on mortality and efficacy outcomes of galantamine-treated patients with Alzheimer’s disease: post-hoc analysis of a randomized placebo-controlled study

  Memantine No memantine Placebo
Placebo Galantamine Placebo Galantamine Memantine vs no memantine
Time to death
n/J (%) 15/245 (6.1) 19/251 (7.6) 41/776 (5.3) 14/773 (1.8)  
 Death rate (per 100 patient-years) 4.49 5.57 4.15 1.39  
 Hazard ratio (95 % CI) 1.25 (0.63; 2.46) 0.33 (0.18; 0.61) 1.16 (0.65; 2.06)
MMSE over time (change from baseline)
 6 months
   n 215 202 673 671  
  Mean (SD) –0.49 (3.41) –0.25 (3.01) –0.22 (2.77) 0.27 (2.63)  
  Effect size (95 % CI) 0.07 (–0.12; 0.27) 0.18 (0.07; 0.29) p = 0.2410
 12 months
   n 215 202 676 672  
  Mean (SD) –1.09 (3.84) –1.09 (3.54) –1.09 (3.45) –0.34 (3.16)  
  Effect size (95 % CI) 0.0 (–0.19; 0.19) 0.23 (0.12; 0.33) p = 1.00
 18 months
   n 215 202 676 672  
  Mean (SD) –1.8 (3.89) –1.86 (4.24) –1.73 (4.03) –0.84 (3.64)  
  Effect size (95 % CI) –0.01 (–0.21; 0.18)   0.23 (0.12; 0.34)   p = 0.8231
 24 months
   n 215 202 676 672  
  Mean (SD) –2.10 (4.14) –2.35 (4.48) –2.15 (4.41) –1.12 (3.87)  
  Effect size (95 % CI) –0.06 (–0.25; 0.13)   0.25 (0.14; 0.36)   p = 0.8832
DAD over time (change from baseline)
 12 months
   n 201 182 620 628  
  Mean (SD) –7.70 (18.34) –6.58 (18.59) –6.10 (15.38) –3.94 (13.29)  
  Effect size (95 % CI) 0.06 (–0.14; 0.26)   0.15 (0.04; 0.26)   p = 0.2227
 24 months
   n 202 182 620 628  
  Mean (SD) –13.33 (20.79) –11.78 (20.76) –9.99 (17.31) –7.11 (15.96)  
  Effect size (95 % CI) 0.07 (–0.13; 0.28)   0.17 (0.06; 0.28)   p = 0.0237
New nursing home placement (change from baseline (for 12 months) or from 12 months (for 24 months))
 12 months
   n 100 81 252 249  
  Number (%) 3 (3) 9 (11.1) 4 (1.6) 3 (1.2)  
  Relative risk (95 % CI) 3.70 (1.04; 13.23) 0.76 (0.17; 3.36)  
  χ2, p value 4.76, p = 0.0292   0.13, p = 0.7153   
 24 months
   n 48 52 149 161  
  Number (%) 1 (2) 4 (7.7) 5 (3.4) 1 (0.6)  
  Relative risk (95 % CI) 3.70 (0.43; 31.89) 0.19 (0.02; 1.57)  
  χ2, p value 1.65, p = 0.1985 3.05, p = 0.0808  
New nursing home placement at 24 months (%) 5 18.8 5 1.8  
  1. DAD Disability Assessment for Dementia, MMSE Mini-Mental State Examination, SD standard deviation
  2. n = the number of death cases; J = the number of subjects in each subgroup