Studies on psychological effects
|
Romero et al. [30]
|
2005
|
USA
| |
Cohort
|
76
|
APOE genotype
|
1 month, 4 months, 10 months
|
Emotional reactions
|
Gooding et al. [25]
|
2006
|
USA
|
REVEAL QRI
|
Qualitative
|
60
|
APOE genotype
|
>1 year
|
Coping
|
Green et al. [23]
|
2009
|
USA
|
REVEAL I
|
RCT
|
162
|
APOE genotype
|
Baseline, 6 weeks, 6 months, 1 year
|
Anxiety, depression, test-related distress
|
Ashida et al. [31]
|
2010
|
USA
|
REVEAL II
|
RCT
|
269
|
APOE genotype
|
Baseline, 6 weeks, 1 year
|
Relation results communication and anxiety, depression and test-related distress
|
Lineweaver et al. [32]
|
2014
|
USA
| |
Case–control
|
144
|
APOE genotype
|
Mean 8.2 months post disclosure
|
Objective and subjective memory functioning
|
Green et al. [29]
|
2014
|
USA
|
REVEAL II
|
RCT
|
343
|
APOE genotype
|
Baseline, 6 weeks, 6 months, 1 year
|
Anxiety, depression, distress
|
Studies on behavioral effects
|
Zick et al. [24]
|
2005
|
USA
|
REVEAL I
|
RCT
|
162
|
APOE genotype
|
6 weeks, 6 months, 1 year
|
Insurance uptake
|
Chao et al. [22]
|
2008
|
USA
|
REVEAL I
|
RCT
|
162
|
APOE genotype
|
1 year
|
Health-related behavior: diet, physical exercise, medication/vitamin intake
|
Vernarelli et al. [33]
|
2010
|
USA
|
REVEAL II
|
RCT
|
272
|
APOE genotype
|
6 weeks
|
Health-related behavior: dietary supplement intake
|
Taylor et al. [34]
|
2010
|
USA
|
REVEAL II
|
RCT
|
276
|
APOE genotype
|
Not reported
|
Insurance uptake
|
Christensen et al. [27]
|
2015
|
USA
|
REVEAL II/III
|
RCT
|
795
|
APOE genotype
|
6 weeks, 1 year
|
Insurance uptake, health-related behavior and other behavior changes
|
Hypothetical Caselli et al. [28]
|
2014
|
USA
| |
Survey
|
4036
|
Hypothetical disclosure
|
Not applicable
|
Anticipated health-related behavior and other behavior changes
|
Studies on social effects
|
Ashida et al. [35]
|
2009
|
USA
|
REVEAL II
|
RCT
|
271
|
APOE genotype
|
6 weeks
|
Results communication
|
Ashida et al. [31]
|
2010
|
USA
|
REVEAL II
|
RCT
|
269
|
APOE genotype
|
Base, 6 weeks, 1 year
|
Relation results communication and anxiety, depression and test-related distress
|
Chilibeck et al. [26]
|
2011
|
Canada/USA
|
REVEAL I
|
Qualitative
|
79
|
APOE genotype
|
Not reported
|
Risk perception in relation to family history
|
Hypothetical Caselli et al. [28]
|
2014
|
USA
| |
Survey
|
4036
|
Hypothetical disclosure
|
Not applicable
|
Anticipated results communication
|