Skip to main content

Table 2 Cognitive test performance in controls and individuals with persistent MPS

From: Prospective longitudinal course of cognition in older subjects with mild parkinsonian signs

  Examination Controls Persistent MPS p value
CERAD total score (0–100) BL 87 (64–100) 84 (60–96) 0.002a
(87 ± 7) (83 ± 8)
1FU 86 (56–100) 82 (44–97) 0.002a
(85 ± 8) (80 ± 8)
2FU 88 (57–100) 83 (50–98) <0.001a
(87 ± 8) (82 ± 9)
TMT-A (s) BL 34 (15–100) 39 (24–81) 0.005a
(36 ± 12) (41 ± 12)
1FU 34 (17–103) 41 (21–71) 0.016a
(36 ± 14) (43 ± 12)
2FU 33 (15–90) 40 (24–110) 0.014a
(36 ± 11) (43 ± 14)
TMT-B (s) BL 80 (34–300) 96 (47–300) 0.050a
(88 ± 33) (105 ± 40)
1FU 76 (26–300) 93 (55–300) <0.001a
(82 ± 34) (107 ± 49)
2FU 73 (25–300) 97 (47–300) 0.001a
(81 ± 37) (112 ± 61)
TMT-B – TMT-A (s) BL 46 (11–185) 54 (8–206) 0.083a
(52 ± 30) (64 ± 40)
1FU 40 (5–243) 51 (13–229) 0.001a
(46 ± 29) (64 ± 43)
2FU 39 (0–230) 52 (19–265) 0.004a
(46 ± 33) (70 ± 54)
Executive domain BL 0.406 ± 1.0 0.136 ± 1.0 0.288
1FU 0.690 ± 1.2 0.215 ± 1.1 0.010
2FU 0.887 ± 1.3 0.368 ± 1.1 0.014
Memory domain BL 0.002 ± 0.8 0.028 ± 0.8 0.862
1FU 0.177 ± 0.8 0.002 ± 0.8 0.157
2FU 0.169 ± 0.9 0.124 ± 0.8 0.463
Language domain BL 0.416 ± 0.7 0.370 ± 0.7 0.956
1FU 0.004 ± 0.7 −0.042 ± 0.7 0.575
2FU 0.343 ± 0.7 0.121 ± 0.7 0.124
Visuospatial domain BL 0.284 ± 0.9 0.221 ± 1.3 0.073
1FU 0.431 ± 0.9 0.074 ± 1.3 0.697
2FU 0.041 ± 1.0 0.488 ± 1.2 0.115
  1. Values are presented as median (range) (mean ± standard deviation) for the CERAD total score and the TMT. For the four subdomains, values are presented as mean ± standard deviation of demographically adjusted z scores
  2. a p values were corrected for age, gender and years of education
  3. BL baseline, CERAD Consortium to Establish a Registry for Alzheimer’s Disease, 1FU first follow-up, 2FU second follow-up, MPS mild parkinsonian signs, TMT Trail Making Test