Table 2 Cognitive test performance in controls and individuals with persistent MPS

CERAD total score (0–100)

BL

87 (64–100)

84 (60–96)

0.002^a

(87 ± 7)

(83 ± 8)

1FU

86 (56–100)

82 (44–97)

0.002^a

(85 ± 8)

(80 ± 8)

2FU

88 (57–100)

83 (50–98)

<0.001^a

(87 ± 8)

(82 ± 9)

TMT-A (s)

BL

34 (15–100)

39 (24–81)

0.005^a

(36 ± 12)

(41 ± 12)

1FU

34 (17–103)

41 (21–71)

0.016^a

(36 ± 14)

(43 ± 12)

2FU

33 (15–90)

40 (24–110)

0.014^a

(36 ± 11)

(43 ± 14)

TMT-B (s)

BL

80 (34–300)

96 (47–300)

0.050^a

(88 ± 33)

(105 ± 40)

1FU

76 (26–300)

93 (55–300)

<0.001^a

(82 ± 34)

(107 ± 49)

2FU

73 (25–300)

97 (47–300)

0.001^a

(81 ± 37)

(112 ± 61)

TMT-B – TMT-A (s)

BL

46 (11–185)

54 (8–206)

0.083^a

(52 ± 30)

(64 ± 40)

1FU

40 (5–243)

51 (13–229)

0.001^a

(46 ± 29)

(64 ± 43)

2FU

39 (0–230)

52 (19–265)

0.004^a

(46 ± 33)

(70 ± 54)

Executive domain

BL

0.406 ± 1.0

0.136 ± 1.0

0.288

1FU

0.690 ± 1.2

0.215 ± 1.1

0.010

2FU

0.887 ± 1.3

0.368 ± 1.1

0.014

Memory domain

BL

0.002 ± 0.8

0.028 ± 0.8

0.862

1FU

0.177 ± 0.8

0.002 ± 0.8

0.157

2FU

0.169 ± 0.9

0.124 ± 0.8

0.463

Language domain

BL

0.416 ± 0.7

0.370 ± 0.7

0.956

1FU

0.004 ± 0.7

−0.042 ± 0.7

0.575

2FU

0.343 ± 0.7

0.121 ± 0.7

0.124

Visuospatial domain

BL

0.284 ± 0.9

0.221 ± 1.3

0.073

1FU

0.431 ± 0.9

0.074 ± 1.3

0.697

2FU

0.041 ± 1.0

0.488 ± 1.2

0.115