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Fig. 9 | Alzheimer's Research & Therapy

Fig. 9

From: Protective effect of melatonin on soluble Aβ1–42-induced memory impairment, astrogliosis, and synaptic dysfunction via the Musashi1/Notch1/Hes1 signaling pathway in the rat hippocampus

Fig. 9

DAPT blocked the effects of melatonin on Notch1, Hes1, and Musashi1 in Aβ1–42-treated hippocampal neurons. a Representative images of immunofluorescent staining for NICD. b Statistical analysis of immunofluorescent staining for NICD. c Representative images and statistical analysis of western blots for NICD. d Representative images and statistical analysis of western blots for Hes1. e Representative images and statistical analysis of western blot for Musashi1. Scale bar = 100 μm. **p < 0.01 compared with control cells; # p < 0.05 and ## p < 0.01 compared with Aβ1–42-treated cells; ^^ p < 0.01 compared with melatonin-treated cells; @@ p < 0.01 compared with Aβ1–42 and melatonin-treated cells. Ctrl control cells, Aβ Aβ1–42-treated cells, Mel melatonin-treated cells, Aβ + Mel Aβ1–42 and melatonin-treated cells, Aβ + Mel + D Aβ1–42, melatonin, and DAPT-treated cells, DAPT DAPT (a γ-secretase inhibitor)-treated cells, DAPI 4′,6-diamidino-2-phenylindole

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Alzheimer's Research & Therapy

ISSN: 1758-9193