Skip to main content
Fig. 8 | Alzheimer's Research & Therapy

Fig. 8

From: Protective effect of melatonin on soluble Aβ1–42-induced memory impairment, astrogliosis, and synaptic dysfunction via the Musashi1/Notch1/Hes1 signaling pathway in the rat hippocampus

Fig. 8

DAPT, an inhibitor of Notch1 signaling, blocked the neuroprotective effects of melatonin against Aβ1–42 in hippocampal neurons. a Representative images of immunofluorescent staining for βIII-tubulin. b Statistical analysis of immunofluorescent staining for βIII-tubulin. c Representative images of immunofluorescent staining for MAP2. d Statistical analysis of immunofluorescent staining for MAP2. Scale bar = 100 μm. **p < 0.01 compared with control cells; ## p < 0.01 compared with Aβ1–42-treated cells; ^^ p < 0.01 compared with melatonin-treated cells; @@ p < 0.01 compared with Aβ1–42 and melatonin-treated cells. Ctrl control cells, 1–42-treated cells, Mel melatonin-treated cells, Aβ + Mel1–42 and melatonin-treated cells, Aβ + Mel + D1–42, melatonin, and DAPT-treated cells, DAPT DAPT (a γ-secretase inhibitor)-treated cells, DAPI 4′,6-diamidino-2-phenylindole

Back to article page