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Fig. 6 | Alzheimer's Research & Therapy

Fig. 6

From: Protective effect of melatonin on soluble Aβ1–42-induced memory impairment, astrogliosis, and synaptic dysfunction via the Musashi1/Notch1/Hes1 signaling pathway in the rat hippocampus

Fig. 6

Melatonin increased Hes1 and Musashi1 expression in soluble Aβ1–42-injected rats. a Representative western blot images for Hes1 in the hippocampus. b Statistical analysis of the relative intensity of Hes1 immunoreactive bands. c Hes1 gene expression in the hippocampus analyzed by qPCR. d Representative images of immunofluorescent staining for Musashi1 in the dentate gyrus (DG) of the hippocampus. e Representative images of immunofluorescent staining for Musashi1 in the CA1 region of the hippocampus. f Representative images of immunofluorescent staining for Musashi1 in the CA3 region of the hippocampus. g Statistical analysis of immunofluorescent staining for Musashi1. h Representative western blot images for Musashi1 in the hippocampus. i Statistical analysis of the relative intensity of Musashi1 immunoreactive bands. Scale bar = 100 μm. *p < 0.05 and **p < 0.01 compared with sham-operated rats; # p < 0.05 and ## p < 0.01 compared with Aβ1–42-injected rats. Ctrl control group, Aβ Aβ1–42-injected group, Mel melatonin-injected group, Aβ + Mel dual Aβ1–42 and melatonin-injected group, DAPI 4′,6-diamidino-2-phenylindole

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Alzheimer's Research & Therapy

ISSN: 1758-9193