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Fig. 5 | Alzheimer's Research & Therapy

Fig. 5

From: Protective effect of melatonin on soluble Aβ1–42-induced memory impairment, astrogliosis, and synaptic dysfunction via the Musashi1/Notch1/Hes1 signaling pathway in the rat hippocampus

Fig. 5

Melatonin upregulated the expression of Notch1 and Notch1 intracellular domain (NICD) in soluble Aβ1–42-injected rats. a Representative images of immunofluorescent staining for NICD in the dentate gyrus (DG) of the hippocampus. b Representative images of immunofluorescent staining for NICD in the CA1 region of the hippocampus. c Representative images of immunofluorescent staining for NICD in the CA3 region of the hippocampus. d Statistical analysis of immunofluorescent staining for NICD. e Representative western blot images for Notch1 in the hippocampus. f Statistical analysis of the relative intensity of Notch1 immunoreactive bands. g Representative western blot images for NICD in the hippocampus. h Statistical analysis of the relative intensity of NICD immunoreactive bands. i Notch1 gene expression in the hippocampus by qPCR. Scale bar = 100 μm. *p < 0.05 and **p < 0.01 compared with sham-operated rats; # p < 0.05 and ## p < 0.01 compared with Aβ1–42-injected rats. Ctrl control group, Aβ Aβ1–42-injected group, Mel melatonin-injected group, Aβ + Mel dual Aβ1–42 and melatonin-injected group, DAPI 4′,6-diamidino-2-phenylindole, NTMF Notch1 transmembrane fragment

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Alzheimer's Research & Therapy

ISSN: 1758-9193