| |
MCI PiB-positive (prodromal AD)
|
AD dementia
|
|---|
|
Number
|
11
|
9
|
|
Demographics
|
|
Age at testing (years)
|
69.7 ± 6.7
|
67.3 ± 7.1
|
|
Education
|
12.5 ± 3.3
|
13.3 ± 2.7
|
|
Gender (M/F)
|
5/6
|
2/7
|
|
ApoE ε3ε3/ε3ε4/ε4ε4
|
4/1/5
|
1/5/3
|
|
Cognitive functions
|
|
Global cognition
|
|
MMSE
|
27.7 ± 3.0
|
22.6 ± 3.3**
|
|
FSIQ
|
92.6 ± 12.2
|
69.2 ± 21.6*
|
|
(z-scores)
|
−0.8 ± 0.9
|
−2.6 ± 1.6
|
|
Episodic memory
|
|
RAVL, learning
|
34.7 ± 10.0
|
20.9 ± 5.7**
|
|
(z-scores)
|
−1.2 ± 1.0
|
−2.5 ± 0.5
|
|
RAVL, delayed recall
|
3.8 ± 3.0
|
1.7 ± 2.2
|
|
(z-scores)
|
−1.8 ± 0.9
|
−2.4 ± 0.6
|
|
Rey, delayed recall
|
12.8 ± 8.1
|
1.2 ± 1.9**
|
|
(z-scores)
|
−1.0 ± 1.2
|
−2.7 ± 0.3
|
- Performance is expressed as mean ± standard deviation to the mean. Z-scores were calculated in comparison to a normative population
- Statistically significant differences between groups are displayed as *p < 0.05; **p < 0.01
-
AD Alzheimer’s disease, ApoE apolipoprotein E, F female, FSIQ full-scale intelligence quotient, M male, MCI mild cognitive impairment, MMSE mini mental state examination, PiB Pittsburgh Compound B, RAVL Rey auditory verbal learning test, Rey Rey-Osterrieth complex figure test
