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Table 1 Summary of group demographics and neuropsychological assessment of cognitive domains

From: Regional tau deposition measured by [18F]THK5317 positron emission tomography is associated to cognition via glucose metabolism in Alzheimer’s disease

 

MCI PiB-positive (prodromal AD)

AD dementia

Number

11

9

Demographics

 Age at testing (years)

69.7 ± 6.7

67.3 ± 7.1

 Education

12.5 ± 3.3

13.3 ± 2.7

 Gender (M/F)

5/6

2/7

 ApoE ε3ε3/ε3ε4/ε4ε4

4/1/5

1/5/3

Cognitive functions

Global cognition

 MMSE

27.7 ± 3.0

22.6 ± 3.3**

 FSIQ

92.6 ± 12.2

69.2 ± 21.6*

 (z-scores)

−0.8 ± 0.9

−2.6 ± 1.6

Episodic memory

 RAVL, learning

34.7 ± 10.0

20.9 ± 5.7**

 (z-scores)

−1.2 ± 1.0

−2.5 ± 0.5

 RAVL, delayed recall

3.8 ± 3.0

1.7 ± 2.2

 (z-scores)

−1.8 ± 0.9

−2.4 ± 0.6

 Rey, delayed recall

12.8 ± 8.1

1.2 ± 1.9**

 (z-scores)

−1.0 ± 1.2

−2.7 ± 0.3

  1. Performance is expressed as mean ± standard deviation to the mean. Z-scores were calculated in comparison to a normative population
  2. Statistically significant differences between groups are displayed as *p < 0.05; **p < 0.01
  3. AD Alzheimer’s disease, ApoE apolipoprotein E, F female, FSIQ full-scale intelligence quotient, M male, MCI mild cognitive impairment, MMSE mini mental state examination, PiB Pittsburgh Compound B, RAVL Rey auditory verbal learning test, Rey Rey-Osterrieth complex figure test