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Table 2 Aβ concentration (pM) in the media of HEK cells transfected with WT presenilin. Aβtotal is the result of the addition of Aβ38, Aβ40, and Aβ42

From: Characterization of FRM-36143 as a new γ-secretase modulator for the potential treatment of familial Alzheimer’s disease

  DMSO FRM-36143 p value
total 4925 ± 185 5130 ± 92 0.161
38 750 ± 62 1548 ± 39 4.8E-05
40 4021 ± 132 3477 ± 120 6.2E-03
42 154 ± 2 105 ± 2 6.5E-06