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Table 2 Aβ concentration (pM) in the media of HEK cells transfected with WT presenilin. Aβtotal is the result of the addition of Aβ38, Aβ40, and Aβ42

From: Characterization of FRM-36143 as a new γ-secretase modulator for the potential treatment of familial Alzheimer’s disease

 

DMSO

FRM-36143

p value

Aβtotal

4925 ± 185

5130 ± 92

0.161

Aβ38

750 ± 62

1548 ± 39

4.8E-05

Aβ40

4021 ± 132

3477 ± 120

6.2E-03

Aβ42

154 ± 2

105 ± 2

6.5E-06

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Alzheimer's Research & Therapy

ISSN: 1758-9193