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Fig. 9 | Alzheimer's Research & Therapy

Fig. 9

From: Characterization of FRM-36143 as a new γ-secretase modulator for the potential treatment of familial Alzheimer’s disease

Fig. 9

FRM-36143 does not inhibit DHCR24. Desmosterol change from DMSO was measured in presence of the positive control E2012, the negative control E2212, and FRM-36143. a Dose–response inhibition of DHCR24 by E2012 (IC50 = 63 nM; desmosterol induction at 1 μM ~ 60-fold). b Desmosterol fold increase for the negative control E2212 and FRM-36143 as compared to the response of E2012 at 1 μM. Data represent mean ± SEM of one or two experiments run in duplicate

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Alzheimer's Research & Therapy

ISSN: 1758-9193