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Fig. 7 | Alzheimer's Research & Therapy

Fig. 7

From: Characterization of FRM-36143 as a new γ-secretase modulator for the potential treatment of familial Alzheimer’s disease

Fig. 7

FRM-36143 induces a sustained change in mouse brain Aβ peptides. Time course of Aβ peptide profile changes in the brain at (a) 10 mg/kg and (b) 30 mg/kg FRM-36143. c pharmacokinetic/pharmacodynamic (PK/PD) modeling of the 30 mg/kg dose. d Unbound brain exposure of FRM-36143 at 10 and 30 mg/kg. Data represent mean ± SEM of 5–8 animals per group

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Alzheimer's Research & Therapy

ISSN: 1758-9193