Fig. 6

FRM-36143 is efficacious at modulating Aβ peptides in the rat brain and CSF. Brain (a, b) and CSF (c, d) Aβ peptide changes are reported as percentage change from the vehicle-treated animals. FRM-36143 led to a reduction of 30 % and 58 % reduction of Aβ₄₂ in brain (a) and CSF (c), respectively. This was accompanied by increases of 2.5-fold and 20-fold of Aβ₃₇ in the brain (b) and CSF (d). Data represent mean ± SEM of 7 animals per group. Unpaired t test: *** p < 0.001