Fig. 5From: Characterization of FRM-36143 as a new γ-secretase modulator for the potential treatment of familial Alzheimer’s diseaseFRM-36143 is efficacious at modulating Aβ peptides in the mouse brain. Brain Aβ42 (a) and Aβ37 (b) are reported as percentage change from the vehicle-treated animals. Aβ42 = 43 % decrease, Aβ37 = 3.2-fold increase. Data represent mean ± SEM of 7–12 animals per group. Unpaired t test: *** p < 0.001Back to article page