Fig. 4

FRM-36143 increases the fourth cleavage step of gamma secretase. Using the step-wise cleavage model for Aβ cleavage, the generation of the tetrapeptide VVIA (Aβ₄₂ → Aβ₃₈) and of the pentapeptide VVIAT (Aβ₄₃ → Aβ₃₈) is increased by FRM-36143 in HEK cells expressing WT presenilin. Data represent mean ± SEM of n = 4. Unpaired t test: ** p < 0.01, *** p < 0.001