Brain perfusion in dementia with Lewy bodies and Alzheimer’s disease: an arterial spin labeling MRI study on prodromal and mild dementia stages

Table 3 Significant changes in relative perfusion in patients with mild dementia

Contrast	Region	Laterality	Extent	Coordinates (x,y,z)			Sensitivity	Specificity
Mild DLB < HC	Caudate nucleus ^∗	R	5128	12	16	6	94	81
		L		–10	14	4
	Middle temporal	L	2456	–54	–20	–14	81	86
	Middle temporal	R	2064	42	–52	8	75	76
	Anterior insula	R	1560	36	36	0	81	100
	Inferior frontal
	Anterior insula	L	1072	–30	22	6	75	90
	Inferior frontal	L	576	–34	12	24	75	67
Mild DLB > HC	Precuneus	L	952	–6	–60	58	50	100
Mild AD < HC	Inferior parietal	L	1640	–46	–42	48	72	86
	Superior parietal	R	1440	16	–62	50	84	67
	Precuneus
	Superior temporal	R	584	44	–48	18	84	76
	Precentral sulcus	L	472	–34	4	44	96	52
	Middle temporal	R	360	62	–42	14	72	81
	Superior temporal	L	352	–42	–42	0	80	76
Mild AD > HC	Putamen	L	352	–30	–4	–12	60	86
	Anterior insula	L	2168	–28	26	2	88	84
	Inferior frontal
	Superior temporal	R	1416	–56	–18	4	94	88
	Caudate nucleus	L	1016	–14	16	–6	81	68
Mild DLB < mild AD	Inferior frontal	R	752	36	38	–2	88	76
	Supramarginal	L	752	–44	–28	34	88	72
	SMA	R	704	12	–6	54	69	92
	Inferior frontal	L	496	–38	12	22	63	80
	Middle temporal	L	480	–64	–20	–10	69	92
Mild AD < mild DLB	Precuneus ^∗	LR	2896	2	–60	52	69	92
	Medial superior frontal	L	704	–2	60	32	69	92
	Medial superior frontal	L	584	–2	46	44	69	92
	Supramarginal	L	496	–56	–30	24	69	92

Extent is expressed in mm³. Coordinates are in the Montreal National Institute space. Sensitivity and specificity are percentages, relative to DLB identification except for comparison between mild AD and HC AD Alzheimer’s disease, DLB dementia with Lewy bodies, HC healthy (elderly) controls, L left hemisphere, R right hemisphere, SMA supplementary motor area
^* p _FWE<0.05

ISSN: 1758-9193