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Table 2 Cerebrospinal fluid biomarkers at baseline and at 3 and 6 months

From: Targeted delivery of nerve growth factor to the cholinergic basal forebrain of Alzheimer’s disease patients: application of a second-generation encapsulated cell biodelivery device

 

BL, median (range)

3 months, median (range)

p Value vs. BL

6 months, median (range)

p Value vs. BL

1–42, ng/L

188 (134–208)

202 (113–207)

1.0

183 (123–206)

0.27

t-tau, ng/L

128 (70–235)

120 (64–256)

1.0

113 (76–187)

0.46

p-tau, ng/L

36 (18–76)

42 (35–48)

1.0

46 (33–55)

0.72

NFL, ng/L

301 (57–557)

1959 (846–2632)

0.07

718 (236–758)

0.07

GFAP, ng/L

586 (395–891)

612 (387–943)

0.72

589 (353–833)

1.0

ChAT activity, nmol/ml/minute

373 (317–447)

367 (279–414)

0.14

358 (337–410)

0.47

AChE activity, nmol/ml/minute

12 (9–22)

10 (9–21)

0.07

10 (9–23)

0.27

  1. Abbreviations: BL baseline, 1–42 amyloid-β peptide 1–42, t-tau total tau, p-tau phosphorylated tau, NFL neurofilament light chain protein, GFAP glial fibrillary acidic protein, ChAT choline acetyltransferase, AChE acetylcholine esterase