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Fig. 3 | Alzheimer's Research & Therapy

Fig. 3

From: Targeted delivery of nerve growth factor to the cholinergic basal forebrain of Alzheimer’s disease patients: application of a second-generation encapsulated cell biodelivery device

Fig. 3

Percentage change from baseline in cerebrospinal fluid (CSF) activities of choline acetyltransferase (ChAT) and acetylcholinesterase (AChE) correlated positively with change from baseline in Mini Mental State Examination (MMSE) score (a and b) and nicotinic binding in whole brain (d and e), respectively. The baseline value for nicotinic binding for patient 1 was extrapolated from an average of baseline values from patients 2–4 and is indicated by a circle. Change from baseline in nicotinic binding correlated positively with change from baseline in MMSE score (c). Change from baseline in AChE activity correlated positively with change from baseline in ChAT activity (f)

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Alzheimer's Research & Therapy

ISSN: 1758-9193