Fig. 5

Change in CSF DHA by APOE status and treatment arm. The effect of DHA treatment vs. placebo on CSF DHA levels by APOE genotype is illustrated. The increases in DHA levels in the CSF were less pronounced in carriers of the ɛ4 allele. All ɛ4 noncarriers had increased CSF DHA levels after allocation to DHA treatment. In contrast, 6 of the 25 ɛ4 carriers did not increase DHA levels after DHA supplementation. There was a suggestion for an interaction effect between APOE genotype and treatment arm on CSF DHA levels (p = 0.07). The data were modeled using multivariate linear regression with the change in CSF DHA as the dependent variable and APOE and treatment arm as the independent variables. Aβ42 amyloid-β42, APOE apolipoprotein E, CSF cerebrospinal fluid, DHA docosahexaenoic acid