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Fig. 3 | Alzheimer's Research & Therapy

Fig. 3

From: The effect of APOE genotype on the delivery of DHA to cerebrospinal fluid in Alzheimer’s disease

Fig. 3

Plasma phospholipid and CSF DHA at 18 months. The distribution of phospholipid and CSF DHA measurements at 18 months by baseline CSF Aβ42 tertiles in participants allocated to DHA (n = 29) is illustrated. a There was no significant difference in plasma phospholipid DHA by Aβ42 tertiles after 18 months of DHA. b and c After 18 months of DHA supplementation, there was a significant decrease in CSF DHA levels in participants in the the first Aβ42 tertile (p = 0.01 for three-way group comparison, p = 0.01 for difference between T1 and T2, and p = 0.007 for difference between T1 and T3) and a significantly lower increase in the CSF-to-plasma DHA ratio (p = 0.05 for three-way group comparison, p = 0.05 for difference between T1 and T2, and p = 0.03 for difference between T1 and T3). The groups were compared using a linear regression model. *p < 0.05 for group comparison. Aβ42 amyloid-β42, CSF cerebrospinal fluid, DHA docosahexaenoic acid

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