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Table 3 Crude and adjusted Cox proportional hazards ratios (95 % CI) of nursing home placement, conversion to moderate dementia, and death in severe dementia, with crude and adjusted ORs (95 % CI) of rapid cognitive decline according to quartiles of cerebrospinal fluid total tau

From: High tau levels in cerebrospinal fluid predict nursing home placement and rapid progression in Alzheimer’s disease

CSF t-tau (ng/L) Nursing home placement (n = 112/234) Conversion to moderate dementia (n = 149/219) Rapid cognitive declinea (n = 57/213) Death in severe dementia (n = 46/234)
  Crude Multivariateb Crude Multivariateb Crude Multivariateb Crude Multivariateb
≥900 2.61 (1.54–4.42)c 2.17 (1.24–3.80)c 2.51 (1.59–3.96)c 2.34 (1.45–3.77)c 2.91 (1.25–6.79)c 3.04 (1.16–8.99)c 2.94 (1.29–6.68)c 2.64 (1.10–6.33)c
681–899 1.79 (1.003–3.21)c 1.72 (0.94–3.14) 1.39 (0.86–2.23) 1.19 (0.72–1.96) 2.05 (0.80–5.26) 1.81 (0.66–4.94) 1.46 (0.56–3.78) 0.94 (0.30–2.90)
511–680 1.42 (0.80–2.51) 1.50 (0.82–2.75) 0.90 (0.56–1.47) 0.97 (0.59–1.59) 0.90 (0.34–2.42) 0.88 (0.30–2.55) 1.39 (0.54–3.61) 1.17 (0.42–3.30)
≤510 1.00 1.00 1.00 1.00 1.00 1.00 1.00 1.00
  1. CSF cerebrospinal fluid
  2. a≥4-point decline in Mini Mental State Examination score per 12 months
  3. bMultivariate models are adjusted for age, sex, living condition, education level, mild to moderate dementia, and Mini Mental State Examination score at baseline
  4. c p < 0.05