Variable
|
NHP (n = 112/234), HR (95 % CI)
|
Conversion to moderate dementia (n = 149/219), HR (95 % CI)
|
Rapid cognitive declinea (n = 57/213), OR (95 % CI)
|
Death in severe dementia (n = 46/234), HR (95 % CI)
|
---|
Age (per year)
|
1.00 (0.97–1.03)
|
0.99 (0.96–1.01)
|
1.00 (0.95–1.04)
|
1.00 (0.96–1.04)
|
Male sex
|
0.56 (0.37– 0.83)b
|
0.93 (0.67– 1.52)
|
0.44 (0.22–0.89)b
|
0.65 (0.34–1.22)
|
Cohabiting
|
0.78 (0.52–1.18)
|
1.52 (1.01–2.30)b
|
1.37 (0.63–3.00)
|
1.10 (0.54–2.22)
|
Education level
| | | | |
≤7 years
|
1.00
|
1.00
|
1.00
|
1.00
|
8–12 years
|
0.74 (0.48–1.15)
|
0.98 (0.67–1.44)
|
2.03 (1.06–3.88)b
|
0.98 (0.51–1.89)
|
≥13 years
|
0.38 (0.22–0.65)b
|
0.76 (0.50–1.16)
|
0.43 (0.17–1.09)
|
0.27 (0.10–0.63)b
|
Mild to moderate dementia at baseline
|
1.74 (1.20–2.53)b
|
1.71 (0.85–3.44)
|
2.99 (1.57–5.69)b
|
3.25 (1.80–5.86)b
|
MMSE at LP (per point)
|
0.86 (0.83–0.90)b
|
0.87 (0.87–0.91)b
|
0.95 (0.88–1.02)
|
0.89 (0.85–0.93)b
|
t-tau above median
|
1.81 (1.25–2.64)b
|
1.86 (1.35–2.58)b
|
2.56 (1.34–4.88)b
|
1.73 (0.95–3.17)
|
p-tau above median
|
1.12 (0.77–1.62)
|
1.35 (0.98–1.88)
|
1.63 (0.86–3.07)
|
1.26 (0.69–2.28)
|
Aβ42 below median
|
1.35 (0.93–1.97)
|
1.21 (0.88–1.67)
|
1.05 (0.56–1.97)
|
1.31 (0.76–2.37)
|
-
Aβ42 amyloid-β 42 peptide, LP lumbar puncture, MMSE Mini Mental State Examination, NHP nursing home placement, p-tau phosphorylated tau, t-tau total tau
-
a≥4-point decline in MMSE per 12 months
-
b
p < 0.05