Table 2 Cox proportional hazards ratios of nursing home placement, conversion to moderate dementia, and death in severe dementia during follow-up and ORs of rapid cognitive decline in univariate analyses

Age (per year)

1.00 (0.97–1.03)

0.99 (0.96–1.01)

1.00 (0.95–1.04)

1.00 (0.96–1.04)

Male sex

0.56 (0.37– 0.83)^b

0.93 (0.67– 1.52)

0.44 (0.22–0.89)^b

0.65 (0.34–1.22)

Cohabiting

0.78 (0.52–1.18)

1.52 (1.01–2.30)^b

1.37 (0.63–3.00)

1.10 (0.54–2.22)

Education level

 ≤7 years

1.00

1.00

1.00

1.00

 8–12 years

0.74 (0.48–1.15)

0.98 (0.67–1.44)

2.03 (1.06–3.88)^b

0.98 (0.51–1.89)

 ≥13 years

0.38 (0.22–0.65)^b

0.76 (0.50–1.16)

0.43 (0.17–1.09)

0.27 (0.10–0.63)^b

Mild to moderate dementia at baseline

1.74 (1.20–2.53)^b

1.71 (0.85–3.44)

2.99 (1.57–5.69)^b

3.25 (1.80–5.86)^b

MMSE at LP (per point)

0.86 (0.83–0.90)^b

0.87 (0.87–0.91)^b

0.95 (0.88–1.02)

0.89 (0.85–0.93)^b

t-tau above median

1.81 (1.25–2.64)^b

1.86 (1.35–2.58)^b

2.56 (1.34–4.88)^b

1.73 (0.95–3.17)

p-tau above median

1.12 (0.77–1.62)

1.35 (0.98–1.88)

1.63 (0.86–3.07)

1.26 (0.69–2.28)

Aβ42 below median

1.35 (0.93–1.97)

1.21 (0.88–1.67)

1.05 (0.56–1.97)

1.31 (0.76–2.37)