Table 2 Cox proportional hazards ratios of nursing home placement, conversion to moderate dementia, and death in severe dementia during follow-up and ORs of rapid cognitive decline in univariate analyses
| Variable | NHP (n = 112/234), HR (95 % CI) | Conversion to moderate dementia (n = 149/219), HR (95 % CI) | Rapid cognitive declinea (n = 57/213), OR (95 % CI) | Death in severe dementia (n = 46/234), HR (95 % CI) |
|---|---|---|---|---|
| Age (per year) | 1.00 (0.97–1.03) | 0.99 (0.96–1.01) | 1.00 (0.95–1.04) | 1.00 (0.96–1.04) |
| Male sex | 0.56 (0.37– 0.83)b | 0.93 (0.67– 1.52) | 0.44 (0.22–0.89)b | 0.65 (0.34–1.22) |
| Cohabiting | 0.78 (0.52–1.18) | 1.52 (1.01–2.30)b | 1.37 (0.63–3.00) | 1.10 (0.54–2.22) |
| Education level | ||||
| ≤7 years | 1.00 | 1.00 | 1.00 | 1.00 |
| 8–12 years | 0.74 (0.48–1.15) | 0.98 (0.67–1.44) | 2.03 (1.06–3.88)b | 0.98 (0.51–1.89) |
| ≥13 years | 0.38 (0.22–0.65)b | 0.76 (0.50–1.16) | 0.43 (0.17–1.09) | 0.27 (0.10–0.63)b |
| Mild to moderate dementia at baseline | 1.74 (1.20–2.53)b | 1.71 (0.85–3.44) | 2.99 (1.57–5.69)b | 3.25 (1.80–5.86)b |
| MMSE at LP (per point) | 0.86 (0.83–0.90)b | 0.87 (0.87–0.91)b | 0.95 (0.88–1.02) | 0.89 (0.85–0.93)b |
| t-tau above median | 1.81 (1.25–2.64)b | 1.86 (1.35–2.58)b | 2.56 (1.34–4.88)b | 1.73 (0.95–3.17) |
| p-tau above median | 1.12 (0.77–1.62) | 1.35 (0.98–1.88) | 1.63 (0.86–3.07) | 1.26 (0.69–2.28) |
| Aβ42 below median | 1.35 (0.93–1.97) | 1.21 (0.88–1.67) | 1.05 (0.56–1.97) | 1.31 (0.76–2.37) |