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Table 3 GM volume regions positively correlated with the scores on the FCSRT for the whole group of patients (group ABC) using VBM

From: Exploring anterograde memory: a volumetric MRI study in patients with mild cognitive impairment

Group (score)

P

Brain region

Side

BA

k

x

y

z

T

ABC (TR), n = 138

P FWE = 0.05

Parahippocampal g.

L

35

212

–26

–15

–27

5.59

Hippocampus

NA

33

–21

–27

–12

5.13

Parahippocampal g.

R

35

154

26

–10

–32

5.48

P = 0.001

Hippocampus

L

NA

1227/4337

–28

–10

–24

5.02

Parahippocampal g.

28, 34–36

818/4337

–26

–15

–27

5.59

Temporal pole

38

281/4337

–31

6

–21

4.25

Temporal lobe

38

905/4337

–31

6

–21

4.25

Amygdala

NA

372/4337

–28

–3

–21

4.23

Parahippocampal g.

R

20, 28, 36

812/1700

27

–15

–33

4.56

Hippocampus

NA

172/1700

–25

–9

–24

3.91

Temporal pole

NA

20/53

37

13

–18

3.39

Hippocampus

NA

99/1200

–25

–9

–24

3.91

ABC (FR), n = 138

P = 0.001

Hippocampus

L

NA

470/1188

–24

–34

–3

3.82

Parahippocampal g.

28, 35

295/1188

–19

–28

–13

3.97

Amygdala

NA

25/1188

–21

–9

–12

3.26

Hippocampus

R

NA

264/572

25

–35

1

3.65

Parahipocampal g.

27

104/572

21

–34

–3

3.76

ABC (DTR), n = 138

P FWE = 0.05

Parahippocampal g.

L

35

25

–26

–15

–27

5.06

P = 0.001

Parahippocampal g.

L

28, 34–36

1646/2401

–26

–15

–27

5.06

Hippocampus

NA

711/2401

–27

–10

–24

4.38

Temporal lobe

20

151/2401

–37

–12

–25

3.29

Amygdala

NA

313/2401

–25

0

–18

3.65

Parahippocampal g.

R

28, 35, 36

496/850

25

–12

–36

4.04

Hippocampus

NA

36/850

27

–10

–25

3.61

Temporal lobe

20

68/850

37

13

–18

3.39

  1. Statistical analyses were performed including age, gender, education level, total GM volume and centre as nuisance covariates, with a threshold of P = 0.05, FWE or P = 0.001, uncorrected, including a minimal k of 50 voxels
  2. GM grey matter, FCSRT Free and Cued Selective Reminding Test, VBM voxel-based morphometry, L left, R right, BA Brodmann area, k cluster size in voxel (specific region’s volume/cluster’s global volume), x, y, z Talairach coordinates, T T value, g. gyrus, DTR delayed total recall, FR free recall, FWE family-wise error, TR total recall