Table 2 Correlation between the studied SNPs of the APOE gene and the risk of AD, presence of APOE isoforms and ApoE serum levels

rs449647 (AT)

15.0 %

21.8 %

Allele T OR 0.63 (95 % CI 0.39–1.01), p 0.07

Underrepresented in carriers of allele T^a,b genotypes AT, TT^a,b

Correlates with allele T^a,c genotypes AT, TT^a,c

Lower ApoE levels in carriers of allele A^d

rs769446 (TC)

5.9 %

6.8 %

n.s.

n.s.

Correlates with allele C,^a,c genotypes TC, CC^a,c

n.s.

rs405509 (TG)

39.8 %

55.9 %

Allele G^a,c

OR 0.52 (95 % CI 0.36–0.75)

Underrepresented in carriers of allele G,^d genotypes TG, GG^a,b

Correlates with allele G,^a,c genotypes TG, GG^a,c

n.s.

rs440446 (CG)

33.5 %

38.6 %

n.s.

Underrepresented in carriers of allele C,^a,c genotypes GC, CC^a,c

Correlates with allele C,^a,c genotypes GC, CC^a,c

n.s.

rs429358 (TC)

28.9 %

9.1 %

Allele C^a,c

OR 4.1 (95 % CI 2.4–6.9)

N/A

N/A

Lower ApoE levels in carriers of allele C,^a,b genotypes CT, CC^a,c

rs7412 (CT)

3.9 %

6.4 %

n.s.

N/A

N/A

Higher ApoE levels in carriers of allele T^d

E4

N/A

N/A

OR 4.7^a,c (95 % CI 2.5–8.6)

N/A

N/A

Lower ApoE^e levels in carriers of E4^a,c

E2

N/A

N/A

OR 0.40 (95 % CI 0.15–1.07), p 0.1

N/A

N/A

Higher ApoE^e levels in carriers of E2^a,b