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Table 2 Alzheimer’s disease-associated deregulation of microRNAs targeting FERMT2 and NUP160

From: miRNA-dependent target regulation: functional characterization of single-nucleotide polymorphisms identified in genome-wide association studies of Alzheimer’s disease

Gene miRNA AD References
FERMT2 hsa-miR-29b-3p Downregulated Cogswell et al. [32], Hebert et al. [33], Nunez-Iglesias et al. [48], Geekiyanage et al. [49], Hebert et al. [35], Kiko et al. [50], Leidinger et al. [37], Tan et al. [51], Villa et al. [52], Denk et al. [34]
hsa-miR-107 Downregulated Hebert et al. [33], Wang et al. [53], Leidinger et al. [37], Muller et al. [54]
hsa-miR-15a-5p Downregulated Cogswell et al. [32], Hebert et al. [33], Nunez-Iglesias et al. [46], Leidinger et al. [37], Denk et al. [34]
hsa-miR-144-5p Downregulated Leidinger et al. [37], Denk et al. [34]
hsa-miR-103a-3p Downregulated Cogswell et al. [32], Hebert et al. [33], Hebert et al. [35], Leidinger et al. [37], Denk et al. [34]
hsa-miR-582-3p Downregulated Hebert et al. [35]
hsa-miR-498 Not Altered Hebert et al. [33]
hsa-miR-29a-5p Not Altered Hebert et al. [35], Denk et al. [34]
hsa-miR-222-3p Not Altered Hebert et al. [33], Lau et al. [38], Denk et al. [34]
hsa-miR-424-5p Upregulated Cogswell et al. [32], Hebert et al. [33], Lau et al. [38], Denk et al. [34]
hsa-miR-3163 Upregulated Denk et al. [34]
NUP160 hsa-miR-1185-1-3p Downregulated Lau et al. [38]
hsa-miR-126-5p Downregulated Cogswell et al. [32], Hebert et al. [35], Leidinger et al. [37], Denk et al. [34]
hsa-miR-133b Downregulated Cogswell et al. [32], Hebert et al. [33], Denk et al. [34]
hsa-miR-323b-3p Upregulated Leidinger et al. [37]
  1. A summary of the miRNAs predicted to target FERMT2 and NUP160, for which alterations in expression have been reported in Alzheimer’s disease (AD; mainly downregulated, upregulated, or not altered; refer to the quoted references). MicroRNAs (miRNA, miR) for which the literature results are ambiguous are not mentioned in the table
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Alzheimer's Research & Therapy

ISSN: 1758-9193