Gene
|
PolymiRTS
|
Minor allele
|
MAF
|
OR
|
95 % CI
|
miRNA
|
PolymiRTS consequence
|
Anticipated effect
|
---|
FERMT2
|
rs7143400
|
T
|
10.08 %
|
1.09
|
1.04–1.15
|
hsa-miR-4504
|
Creation perfect seed
|
Decreased expression
|
MS4A2
|
rs2847655
|
C
|
41.09 %
|
0.90
|
0.87–0.93
|
hsa-miR-585-3p
|
Disruption perfect seed
|
Increased expression
|
hsa-miR-3945
|
Creation perfect seed
|
Decreased expression
|
| | | | | |
hsa-miR-6876-3p
|
Disruption perfect seed
|
Increased expression
|
MS4A6A
|
rs610932
|
A
|
42.49 %
|
0.91
|
0.88–0.94
|
hsa-miR-626
|
Disruption perfect seed
|
Increased expression
|
hsa-miR-6888-3p
|
Creation perfect seed
|
Decreased expression
|
NUP160
|
rs9909
|
C
|
33.75 %
|
0.93
|
0.90–0.96
|
hsa-miR-3976
|
Creation perfect seed
|
Decreased expression
|
hsa-miR-1185-1-3p
|
Disruption perfect seed
|
Increased expression
|
-
MAF minor allele frequency, PolymiRTS polymorphism in a microRNA target site, miR and miRNA microRNA
- A summary of the genes, single-nucleotide polymorphisms, minor allele identity relative to 3′ untranslated region strand, MAF, and OR [95 % CI] (in the International Genomics of Alzheimer’s Project database discovery or meta-analysis study when available [8]), affected miRNAs, the effects of the Alzheimer’s disease-associated PolymiRTSs identified in this study, and the predicted consequences