miRNA-dependent target regulation: functional characterization of single-nucleotide polymorphisms identified in genome-wide association studies of Alzheimer’s disease

Table 1 Alzheimer’s disease-associated polymorphisms in a microRNA target sites identified in silico, with the corresponding minor allele frequency, odds ratio, and potential effect on microRNA binding

Gene	PolymiRTS	Minor allele	MAF	OR	95 % CI	miRNA	PolymiRTS consequence	Anticipated effect
FERMT2	rs7143400	T	10.08 %	1.09	1.04–1.15	hsa-miR-4504	Creation perfect seed	Decreased expression
MS4A2	rs2847655	C	41.09 %	0.90	0.87–0.93	hsa-miR-585-3p	Disruption perfect seed	Increased expression
MS4A2	rs2847655	C	41.09 %	0.90	0.87–0.93	hsa-miR-3945	Creation perfect seed	Decreased expression
						hsa-miR-6876-3p	Disruption perfect seed	Increased expression
MS4A6A	rs610932	A	42.49 %	0.91	0.88–0.94	hsa-miR-626	Disruption perfect seed	Increased expression
MS4A6A	rs610932	A	42.49 %	0.91	0.88–0.94	hsa-miR-6888-3p	Creation perfect seed	Decreased expression
NUP160	rs9909	C	33.75 %	0.93	0.90–0.96	hsa-miR-3976	Creation perfect seed	Decreased expression
NUP160	rs9909	C	33.75 %	0.93	0.90–0.96	hsa-miR-1185-1-3p	Disruption perfect seed	Increased expression

MAF minor allele frequency, PolymiRTS polymorphism in a microRNA target site, miR and miRNA microRNA
A summary of the genes, single-nucleotide polymorphisms, minor allele identity relative to 3′ untranslated region strand, MAF, and OR [95 % CI] (in the International Genomics of Alzheimer’s Project database discovery or meta-analysis study when available [8]), affected miRNAs, the effects of the Alzheimer’s disease-associated PolymiRTSs identified in this study, and the predicted consequences

ISSN: 1758-9193