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Table 1 Alzheimer’s disease-associated polymorphisms in a microRNA target sites identified in silico, with the corresponding minor allele frequency, odds ratio, and potential effect on microRNA binding

From: miRNA-dependent target regulation: functional characterization of single-nucleotide polymorphisms identified in genome-wide association studies of Alzheimer’s disease

Gene PolymiRTS Minor allele MAF OR 95 % CI miRNA PolymiRTS consequence Anticipated effect
FERMT2 rs7143400 T 10.08 % 1.09 1.04–1.15 hsa-miR-4504 Creation perfect seed Decreased expression
MS4A2 rs2847655 C 41.09 % 0.90 0.87–0.93 hsa-miR-585-3p Disruption perfect seed Increased expression
hsa-miR-3945 Creation perfect seed Decreased expression
       hsa-miR-6876-3p Disruption perfect seed Increased expression
MS4A6A rs610932 A 42.49 % 0.91 0.88–0.94 hsa-miR-626 Disruption perfect seed Increased expression
hsa-miR-6888-3p Creation perfect seed Decreased expression
NUP160 rs9909 C 33.75 % 0.93 0.90–0.96 hsa-miR-3976 Creation perfect seed Decreased expression
hsa-miR-1185-1-3p Disruption perfect seed Increased expression
  1. MAF minor allele frequency, PolymiRTS polymorphism in a microRNA target site, miR and miRNA microRNA
  2. A summary of the genes, single-nucleotide polymorphisms, minor allele identity relative to 3′ untranslated region strand, MAF, and OR [95 % CI] (in the International Genomics of Alzheimer’s Project database discovery or meta-analysis study when available [8]), affected miRNAs, the effects of the Alzheimer’s disease-associated PolymiRTSs identified in this study, and the predicted consequences