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Table 1 Alzheimer’s disease-associated polymorphisms in a microRNA target sites identified in silico, with the corresponding minor allele frequency, odds ratio, and potential effect on microRNA binding

From: miRNA-dependent target regulation: functional characterization of single-nucleotide polymorphisms identified in genome-wide association studies of Alzheimer’s disease

Gene

PolymiRTS

Minor allele

MAF

OR

95 % CI

miRNA

PolymiRTS consequence

Anticipated effect

FERMT2

rs7143400

T

10.08 %

1.09

1.04–1.15

hsa-miR-4504

Creation perfect seed

Decreased expression

MS4A2

rs2847655

C

41.09 %

0.90

0.87–0.93

hsa-miR-585-3p

Disruption perfect seed

Increased expression

hsa-miR-3945

Creation perfect seed

Decreased expression

      

hsa-miR-6876-3p

Disruption perfect seed

Increased expression

MS4A6A

rs610932

A

42.49 %

0.91

0.88–0.94

hsa-miR-626

Disruption perfect seed

Increased expression

hsa-miR-6888-3p

Creation perfect seed

Decreased expression

NUP160

rs9909

C

33.75 %

0.93

0.90–0.96

hsa-miR-3976

Creation perfect seed

Decreased expression

hsa-miR-1185-1-3p

Disruption perfect seed

Increased expression

  1. MAF minor allele frequency, PolymiRTS polymorphism in a microRNA target site, miR and miRNA microRNA
  2. A summary of the genes, single-nucleotide polymorphisms, minor allele identity relative to 3′ untranslated region strand, MAF, and OR [95 % CI] (in the International Genomics of Alzheimer’s Project database discovery or meta-analysis study when available [8]), affected miRNAs, the effects of the Alzheimer’s disease-associated PolymiRTSs identified in this study, and the predicted consequences