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Fig. 1 | Alzheimer's Research & Therapy

Fig. 1

From: miRNA-dependent target regulation: functional characterization of single-nucleotide polymorphisms identified in genome-wide association studies of Alzheimer’s disease

Fig. 1

In silico approach for assessing score thresholds for identification of microRNA (miRNA) target sites and polymorphisms in a microRNA target site (PolymiRTSs). a A graphical representation of the “basic score filtering” in TargetScan. The “context +” scores for each miRNA binding site are plotted on the x-axis, and the number of counts with which each score was found is plotted on the y-axis. The top 5 % context + scores had a value below −0.318. b A graphical representation of the “score difference filter” in TargetScan. The percentage change in the context + scores for each miRNA binding site (due to the presence of a PolymiRTS) is plotted on the x-axis, and the number of counts with which each change in score was found is plotted on the y-axis. The top 5 % context + score changes had a value below −8.25 % or above 8.25

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Alzheimer's Research & Therapy

ISSN: 1758-9193