Table 1 Demographics and baseline characteristics of study participants by cohort (all randomized participants)
Cohort 1 | Cohort 2 | Cohort 3 | Cohort 4 | Total | |
|---|---|---|---|---|---|
(n = 6) | (n = 6) | (n = 6) | (n = 6) | (N = 24) | |
Age (years) | 62 (4.3) | 64 (6.4) | 66 (1.7) | 63 (3.3) | 64 (4.3) |
Sex (men), n (%) | 6 (100.0) | 5 (83.3) | 6 (100.0) | 5 (83.3) | 22 (91.7) |
Race, n (%) | |||||
White | 6 (100.0) | 6 (100.0) | 5 (83.3) | 6 (100.0) | 23 (95.8) |
Black or African American | 0 | 0 | 1 (16.7) | 0 | 1 (4.2) |
Ethnicity, n (%) | |||||
Not Hispanic or Latino | 6 (100.0) | 6 (100.0) | 6 (100.0) | 6 (100.0) | 24 (100.0) |
Weight (kg) | 83 (10.8) | 72 (8.3) | 77 (5.6) | 79 (10.6) | 78 (9.6) |
Height (cm) | 176 (7.8) | 170 (9.5) | 171 (9.2) | 173 (7.6) | 172 (8.4) |
BMI (kg/m2) | 27.1 (3.8) | 25 (2.3) | 26.6 (2.7) | 26.6 (3.5) | 26.3 (3.0) |
Total MMSE at screening | 29.2 (0.8) | 29.0 (1.3) | 29.7 (0.5) | 29.7 (0.8) | 29.4 (0.9) |
Aβ1-42 (pg/ml) | 393.2 (26.4) | 380.6 (44.1) | 326.1 (75.4) | 319.2 (97.6) | 354.8 (70.6) |
T-tau (pg/ml) | 74.5 (20.0) | 62.7 (28.9) | 46.7 (20.6) | 50.7 (21.9) | 58.6 (24.3) |
P-tau181P (pg/ml) | 30.7 (8.2) | 22.2 (4.9) | 20.4 (6.9) | 24.9 (13.0) | 24.6 (9.1) |
APOE ε4 carrier | |||||
Yes | 1 (16.7) | 1 (16.7) | 0 | 2 (33.3) | 4 (16.7) |
No | 4 (66.7) | 3 (50.0) | 5 (83.3) | 4 (66.7) | 16 (66.7) |
Unknown | 1 (16.7) | 2 (33.3) | 1 (16.7) | 0 | 4 (16.7) |