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Table 1 Correlation tests between CRTC1 methylation levels and Alzheimer's disease (AD)-related pathological changes

From: CRTC1 gene is differentially methylated in the human hippocampus in Alzheimer’s disease

AD-related changes

Prom1 methylation level

Prom2 methylation

Spearman coefficient

raw p-value

Spearman coefficient

raw p-value

p-tau area

−0.903

0.000024a

−0.753

0.002

averaged β-amyloid area

−0.761

0.003

−0.651

0.012

APS

−0.761

0.003

−0.640

0.014

  1. p-tau hyperphosphorylated tau; APS amyloid plaque score
  2. adenotes those comparisons below the Bonferroni-corrected p-value = 0.008