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Table 1 Characteristics of the Norwegian and Swedish cohorts

From: Cerebrospinal fluid soluble TREM2 in aging and Alzheimer’s disease

    

p value

 

Controls

MCI

AD

Controls–MCI

Controls–AD

MCI–AD

Norwegian cohort

n = 50

n = 21

n = 29

   

Gender

      

 Women

25

12

13

   

 Men

25

9

16

   

Age

66 (50–86)

67 (55–75)

68 (56–75)

   

MMSE

29 (29–30)

27 (26–29)

20 (17–24)

*

*

*

CSF Aβ42 (pg/ml)

1010 (880–1188)

494 (356–531)

500 (386–553)

*

*

0.43

CSF T-tau (pg/ml)

307 (201–391)

628 (497–927)

772 (647–1143)

*

*

0.06

CSF P-tau (pg/ml)

51 (38–61)

75 (62–111)

72 (67–91)

*

*

1.00

ApoE genotype

      

 E2/E3

8

1

   

 E2/E4

 

1

   

 E3/E3

35

5

5

   

 E3/E4

6

8

12

   

 E4/E4

8

10

   

 Not known

1

     

CSF sTREM2 (ng/ml)

4.4 (3.0–5.7)

4.1 (2.4–5.9)

4.8 (3.5–7.1)

0.42

0.17

0.11

Swedish cohort

n = 25

 

n = 25

   

Gender

      

 Women

17

 

18

   

 Men

8

 

7

   

Age

62 (43–80)

 

79 (61–86)

   

MMSE

29 (28–30)

 

18 (13–22)

 

*

 

CSF Aβ42 (pg/ml)

520 (469–597)

 

340 (265–430)

 

*

 

CSF T-tau (pg/ml)

380 (233–480)

 

670 (490–895)

 

*

 

CSF P-tau (pg/ml)

44 (36–61)

 

80 (69–96)

 

*

 

ApoE genotype

      

 E2/E3

5

 

1

   

 E2/E4

1

 

1

   

 E3/E3

14

 

4

   

 E3/E4

4

 

15

   

 E4/E4

1

 

4

   

CSF sTREM2 (ng/ml)

3.2 (2.8–5.0)

 

3.8 (2.6–5.6)

 

0.76

 
  1. Descriptive statistics of gender, age, MMSE, ApoE genotype and CSF biomarker data of AD, MCI and control patients of the two cohorts
  2. Data are presented as median (interquartile range), except age which is presented as median (minimum–maximum). Two-tailed p values obtained by Mann–Whitney U test for group comparison
  3. *p < 0.001
  4. Aβ42 amyloid beta 1–42, AD Alzheimer’s disease, ApoE apolipoprotein E, CSF cerebrospinal fluid, MCI mild cognitive impairment, MMSE Mini-Mental State Examination, P-tau phosphorylated Tau, sTREM2 soluble triggering receptor expressed on myeloid cells 2, T-tau total Tau