From: Mini Mental State Examination and Logical Memory scores for entry into Alzheimer’s disease trials
Sensitivity | Specificity | PPV | NPV | |
---|---|---|---|---|
LM-II score (A4 Trial) (10,741 normal cognition; 5883 MCI) | ||||
Cutoff score = 6 | 40.5 | 91.1 | 71.4 | 73.6 |
LM-II score (BAN2401 Trial) | ||||
50–64 years (2315 normal cognition; 897 MCI) | ||||
Cutoff score = 15 | 92.1 | 27.8 | 33.1 | 90.1 |
65–69 years (2092 normal cognition; 909 MCI) | ||||
Cutoff score = 12 | 77.7 | 52.0 | 41.3 | 84.3 |
70–74 years (2083 normal cognition; 1182 MCI) | ||||
Cutoff score = 11 | 78.1 | 57.3 | 50.9 | 82.1 |
75–79 years (1824 normal cognition; 1270 MCI) | ||||
Cutoff score = 9 | 67.0 | 70.0 | 60.9 | 75.2 |
80–90 years (2212 normal cognition; 1472 MCI) | ||||
Cutoff score = 7 | 54.8 | 80.7 | 65.4 | 72.8 |
LM-II score (ADNI 2) | ||||
16+ years of education (6583 normal cognition; 3202 MCI) | ||||
Cutoff score = 9 | 66.4 | 80.2 | 62.1 | 83.0 |
Cutoff score = 10 | 73.4 | 73.0 | 57.0 | 84.9 |
Cutoff score = 11 | 79.8 | 64.4 | 52.2 | 86.7 |
8–15 years of education (4061 normal cognition; 2576 MCI) | ||||
Cutoff score = 5 | 35.6 | 91.3 | 72.2 | 69.1 |
Cutoff score = 6 | 44.0 | 86.4 | 67.2 | 70.9 |
Cutoff score = 7 | 52.5 | 80.4 | 62.9 | 72.7 |
Cutoff score = 8 | 60.2 | 73.1 | 58.7 | 74.3 |
Cutoff score = 9 | 68.4 | 64.5 | 55.0 | 76.3 |
0–7 years of education (51 normal cognition; 85 MCI) | ||||
Cutoff score = 3 | 33.7 | 82.4 | 76.3 | 42.4 |
Cutoff score = 4 | 44.2 | 76.5 | 76 | 44.8 |
Cutoff score = 5 | 54.7 | 74.5 | 78.3 | 49.4 |