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Table 4 Factors affecting the long-term outcome with IADL or PSMS score as dependent variables

From: Mild versus moderate stages of Alzheimer's disease: three-year outcomes in a routine clinical setting of cholinesterase inhibitor therapy

  IADL PSMS
Significant predictors in final mixed modelsa β 95 % CI p β 95 % CI p
Percentage of variance accounted for, all fixed terms 56.0 %, p <0.001   39.9 %, p <0.001  
Fixed terms       
 Intercept 2.375 −3.349, 8.099 0.414 4.844 2.154, 7.534 <0.001
 Time in months from baseline 0.515 0.407, 0.623 <0.001 0.188 0.162, 0.213 <0.001
 Baseline assessment score 1.431 0.926, 1.936 <0.001 0.900 0.789, 1.011 <0.001
 Baseline assessment score2 −0.016 −0.029, −0.003 0.019    ns
 Time in months × baseline assessment score −0.013 −0.017, −0.008 <0.001    ns
 Time in months2 × baseline assessment score −0.0001 −0.0002, −0.00002 0.010    ns
Background variables       
 MMSE score at baseline −0.195 −0.374, −0.016 0.033 −0.203 −0.339, −0.067 0.004
 ChEI doseb −0.025 −0.048, −0.002 0.037 −0.019 −0.035, −0.003 0.021
Random terms (variance)       
 Intercept 5.089 3.832, 6.757 <0.001 1.762 1.048, 2.963 <0.001
 Time in months 0.008 0.005, 0.012 <0.001 0.017 0.013, 0.024 <0.001
  1. Sex, apolipoprotein E genotype, solitary living, age at onset, age at baseline, years of education, number of medications and specific concomitant medications used at baseline, as well as the variable comparing the ChEI agents, were not significant predictors in the models. β values were unstandardized and are expressed per 1 unit increase for continuous variables and for the condition present in dichotomous variables
  2. aBaseline assessment score = IADL or PSMS, respectively
  3. bMean percentage of the maximum recommended dose; that is, 10 mg for donepezil, 12 mg for rivastigmine and 24 mg for galantamine
  4. ChEI cholinesterase inhibitors, CI confidence interval, IADL Instrumental Activities of Daily Living, MMSE Mini-Mental State Examination, ns not significant, PSMS Physical Self-Maintenance Scale