Reference tissue normalization in longitudinal 18F-florbetapir positron emission tomography of late mild cognitive impairment

Table 1 Summary of previous longitudinal ¹⁸F-florbetapir PET studies for comparison between reference tissues for normalization of PET activity

	Brendel et al. [20]	Chen et al. [21]	Landau et al. [22]
Reference regions	Whole cerebellum	Whole cerebellum	Cerebellar gray matter
	Brainstem	Pons	Whole cerebellum
	White matter	White matter	White matter
			Brainstem/pons
			Composite ROI
Subject groups	MCI (n = 483)	MCI (n = 187)	CSF- (14)
	AD (n = 163)	AD (n = 31)	CSF+ (n = 91)
	HC (n = 316)	HC (n = 114)
PET radiotracer	¹⁸F-florbetapir	¹⁸F-florbetapir	¹⁸F-florbetapir
Image analysis	Mean SUV/SUVR	Mean SUVR	Mean SUVR
Evaluation method	Discrimination power between subject groups, variability in longitudinal increase in Aβ-PET	Longitudinal increase in Aβ-PET and association with clinical decline	Physiological plausible longitudinal increase in Aβ-PET
Best reference region	White matter/brainstem with partial volume correction	White matter	Reference regions containing white matter

Aβ amyloid-β, AD Alzheimer’s disease, CSF cerebrospinal fluid, HC healthy controls, MCI mild cognitive impairment, PET positron emission tomography, ROI region of interest, SUV standardized uptake value, SUVR standardized uptake value ratio

ISSN: 1758-9193