Alzheimer’s Disease Assessment Scale–Cognitive subscale variants in mild cognitive impairment and mild Alzheimer’s disease: change over time and the effect of enrichment strategies

Table 5 Signal-to-noise ratio for change in ADAS-Cog variants over 24 months in MCI cohorts

	ADAS-Cog 3		ADAS-Cog 5		ADAS-Cog 11		ADAS-Cog 13
	SNR	95 % CI	SNR	95 % CI	SNR	95 % CI	SNR	95 % CI
MCI	0.42	0.20–0.61	0.42	0.19–0.63	0.37	0.15–0.57	0.39	0.16–0.60
t-Tau/Aβ	0.43	0.15–0.69	0.45	0.16–0.73	0.39	0.11–0.65	0.42	0.12–0.69
Aβ	0.47	0.22–0.70	0.47	0.21–0.70	0.41	0.17–0.64	0.44	0.19–0.67
ApoE4+	0.53	0.24–0.82	0.61	0.33–0.88	0.53	0.26–0.78	0.60	0.33–0.86
t-Tau	0.45	0.14–0.75	0.52	0.18–0.84	0.39	0.09–0.66	0.45	0.14–0.77
p-Tau	0.43	0.19–0.65	0.43	0.17–0.66	0.37	0.12–0.61	0.39	0.14–0.63

Aβ amyloid β, ADAS-Cog Alzheimer’s Disease Assessment Scale–Cognitive subscale, ApoE4 apolipoprotein E ε4, CI confidence interval, MCI mild cognitive impairment, MMSE Mini Mental State Examination, SNR signal-to-noise ratio
SNR estimates corrected for covariates, reported for an ApoE4-positive 75-year-old woman, baseline ADAS-Cog 11 of 10, baseline MMSE of 28. CIs were obtained via bootstrapping

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