Skip to main content

Table 5 Signal-to-noise ratio for change in ADAS-Cog variants over 24 months in MCI cohorts

From: Alzheimer’s Disease Assessment Scale–Cognitive subscale variants in mild cognitive impairment and mild Alzheimer’s disease: change over time and the effect of enrichment strategies

  ADAS-Cog 3 ADAS-Cog 5 ADAS-Cog 11 ADAS-Cog 13
  SNR 95 % CI SNR 95 % CI SNR 95 % CI SNR 95 % CI
MCI 0.42 0.20–0.61 0.42 0.19–0.63 0.37 0.15–0.57 0.39 0.16–0.60
t-Tau/Aβ 0.43 0.15–0.69 0.45 0.16–0.73 0.39 0.11–0.65 0.42 0.12–0.69
0.47 0.22–0.70 0.47 0.21–0.70 0.41 0.17–0.64 0.44 0.19–0.67
ApoE4+ 0.53 0.24–0.82 0.61 0.33–0.88 0.53 0.26–0.78 0.60 0.33–0.86
t-Tau 0.45 0.14–0.75 0.52 0.18–0.84 0.39 0.09–0.66 0.45 0.14–0.77
p-Tau 0.43 0.19–0.65 0.43 0.17–0.66 0.37 0.12–0.61 0.39 0.14–0.63
  1. amyloid β, ADAS-Cog Alzheimer’s Disease Assessment Scale–Cognitive subscale, ApoE4 apolipoprotein E ε4, CI confidence interval, MCI mild cognitive impairment, MMSE Mini Mental State Examination, SNR signal-to-noise ratio
  2. SNR estimates corrected for covariates, reported for an ApoE4-positive 75-year-old woman, baseline ADAS-Cog 11 of 10, baseline MMSE of 28. CIs were obtained via bootstrapping