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Table 4 ADAS-Cog score and change from baseline up to 24 months for subjects with mild AD

From: Alzheimer’s Disease Assessment Scale–Cognitive subscale variants in mild cognitive impairment and mild Alzheimer’s disease: change over time and the effect of enrichment strategies

 

ADAS-Cog 3

ADAS-Cog 5

ADAS-Cog 13

 

Number of subjects

Score

CFB

Number of subjects

Score

CFB

Number of subjects

Score

CFB

Mild AD (non-enriched)

 Baseline/screen

97

15.95 ± 4.15

 

97

26.20 ± 5.31

 

97

29.91 ± 7.44

 

 Month 6

95

16.95 ± 4.83

1.10 ± 3.85

95

27.62 ± 6.25

1.52 ± 4.32

95

31.86 ± 8.51

2.10 ± 4.79

 Month 12

97

17.77 ± 5.29

1.82 ± 3.91

97

28.84 ± 6.75

2.64 ± 4.39

97

34.26 ± 10.43

4.35 ± 5.89

 Month 24

40

18.68 ± 5.82

3.81 ± 5.12

40

30.27 ± 7.20

5.48 ± 6.13

38

37.17 ± 12.38

9.46 ± 9.15

Mild AD+ (enriched)

 Baseline/screen

90

16.24 ± 4.12

 

90

26.62 ± 5.23

 

90

30.52 ± 7.35

 

 Month 6

88

17.17 ± 4.89

1.03 ± 3.92

88

27.92 ± 6.32

1.41 ± 4.37

88

32.36 ± 8.58

1.99 ± 4.84

 Month 12

90

18.19 ± 5.17

1.96 ± 3.98

90

29.42 ± 6.59

2.80 ± 4.46

90

35.08 ± 10.34

4.57 ± 6.03

 Month 24

37

19.15 ± 5.77

4.06 ± 5.23

35

30.79 ± 7.18

5.63 ± 6.34

35

37.99 ± 12.51

9.77 ± 9.40

  1. AD Alzheimer’s disease, ADAS-Cog Alzheimer’s Disease Assessment Scale–Cognitive subscale, CFB change from baseline
  2. Data are presented as mean ± standard deviation. Increased score on ADAS-Cog indicates cognitive worsening