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Table 4 ADAS-Cog score and change from baseline up to 24 months for subjects with mild AD

From: Alzheimer’s Disease Assessment Scale–Cognitive subscale variants in mild cognitive impairment and mild Alzheimer’s disease: change over time and the effect of enrichment strategies

  ADAS-Cog 3 ADAS-Cog 5 ADAS-Cog 13
  Number of subjects Score CFB Number of subjects Score CFB Number of subjects Score CFB
Mild AD (non-enriched)
 Baseline/screen 97 15.95 ± 4.15   97 26.20 ± 5.31   97 29.91 ± 7.44  
 Month 6 95 16.95 ± 4.83 1.10 ± 3.85 95 27.62 ± 6.25 1.52 ± 4.32 95 31.86 ± 8.51 2.10 ± 4.79
 Month 12 97 17.77 ± 5.29 1.82 ± 3.91 97 28.84 ± 6.75 2.64 ± 4.39 97 34.26 ± 10.43 4.35 ± 5.89
 Month 24 40 18.68 ± 5.82 3.81 ± 5.12 40 30.27 ± 7.20 5.48 ± 6.13 38 37.17 ± 12.38 9.46 ± 9.15
Mild AD+ (enriched)
 Baseline/screen 90 16.24 ± 4.12   90 26.62 ± 5.23   90 30.52 ± 7.35  
 Month 6 88 17.17 ± 4.89 1.03 ± 3.92 88 27.92 ± 6.32 1.41 ± 4.37 88 32.36 ± 8.58 1.99 ± 4.84
 Month 12 90 18.19 ± 5.17 1.96 ± 3.98 90 29.42 ± 6.59 2.80 ± 4.46 90 35.08 ± 10.34 4.57 ± 6.03
 Month 24 37 19.15 ± 5.77 4.06 ± 5.23 35 30.79 ± 7.18 5.63 ± 6.34 35 37.99 ± 12.51 9.77 ± 9.40
  1. AD Alzheimer’s disease, ADAS-Cog Alzheimer’s Disease Assessment Scale–Cognitive subscale, CFB change from baseline
  2. Data are presented as mean ± standard deviation. Increased score on ADAS-Cog indicates cognitive worsening