Table 3 ADAS-Cog scores and change from baseline up to 36 months for patients with MCI
ADAS-Cog 3 | ADAS-Cog 5 | ADAS-Cog 13 | |||||||
|---|---|---|---|---|---|---|---|---|---|
Number of subjects | Score | CFB | Number of subjects | Score | CFB | Number of subjects | Score | CFB | |
MCI (non-enriched) | |||||||||
Baseline/screen | 382 | 8.23 ± 3.76 | 382 | 13.96 ± 6.17 | 382 | 15.23 ± 6.68 | |||
Month 6 | 376 | 8.30 ± 4.14 | 0.01 ± 2.99 | 375 | 14.00 ± 6.68 | −0.07 ± 4.01 | 375 | 15.28 ± 7.25 | −0.07 ± 4.37 |
Month 12 | 381 | 8.09 ± 4.42 | −0.15 ± 3.09 | 380 | 13.72 ± 7.09 | −0.23 ± 3.95 | 379 | 14.97 ± 7.83 | −0.24 ± 4.49 |
Month 24 | 382 | 8.94 ± 5.23 | 0.71 ± 3.56 | 382 | 15.09 ± 8.30 | 1.13 ± 4.87 | 382 | 16.57 ± 9.41 | 1.34 ± 5.68 |
Month 36 | 169 | 9.02 ± 5.34 | 1.23 ± 4.00 | 168 | 15.11 ± 8.58 | 1.95 ± 5.58 | 168 | 16.89 ± 10.18 | 2.59 ± 6.89 |
MCI+ (enriched) | |||||||||
Baseline/screen | 206 | 9.43 ± 3.92 | 206 | 16.12 ± 6.28 | 206 | 17.52 ± 6.81 | |||
Month 6 | 204 | 9.71 ± 4.28 | 0.23 ± 3.17 | 203 | 16.38 ± 6.75 | 0.14 ± 4.18 | 203 | 17.84 ± 7.22 | 0.19 ± 4.56 |
Month 12 | 206 | 9.57 ± 4.63 | 0.14 ± 3.43 | 205 | 16.24 ± 7.21 | 0.16 ± 4.10 | 205 | 17.75 ± 8.01 | 0.28 ± 4.69 |
Month 24 | 206 | 10.91 ± 5.42 | 1.48 ± 3.78 | 206 | 18.32 ± 8.49 | 2.21 ± 5.20 | 206 | 20.15 ± 9.85 | 2.63 ± 6.24 |
Month 36 | 89 | 11.37 ± 5.72 | 2.55 ± 4.40 | 89 | 18.96 ± 9.00 | 3.82 ± 6.03 | 89 | 21.42 ± 11.01 | 5.02 ± 7.60 |
MCI− (biomarker − negative) | |||||||||
Baseline/screen | 176 | 6.82 ± 3.02 | 176 | 17.52 ± 6.81 | 176 | 12.55 ± 5.43 | |||
Month 6 | 172 | 6.62 ± 3.25 | −0.24 ± 2.75 | 172 | 17.84 ± 7.22 | −0.31 ± 3.79 | 172 | 12.26 ± 6.03 | −0.38 ± 4.12 |
Month 12 | 175 | 6.35 ± 3.45 | −0.50 ± 2.69 | 175 | 17.75 ± 8.01 | −0.68 ± 3.73 | 174 | 11.69 ± 6.20 | −0.85 ± 4.18 |
Month 24 | 176 | 6.63 ± 3.88 | −0.19 ± 3.06 | 176 | 20.15 ± 9.85 | −0.11 ± 4.12 | 176 | 12.37 ± 6.80 | −0.18 ± 4.51 |
Month 36 | 80 | 6.40 ± 3.35 | −0.25 ± 2.88 | 79 | 21.42 ± 11.01 | −0.16 ± 4.15 | 79 | 11.78 ± 5.95 | −0.15 ± 4.69 |