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Table 3 ADAS-Cog scores and change from baseline up to 36 months for patients with MCI

From: Alzheimer’s Disease Assessment Scale–Cognitive subscale variants in mild cognitive impairment and mild Alzheimer’s disease: change over time and the effect of enrichment strategies

  ADAS-Cog 3 ADAS-Cog 5 ADAS-Cog 13
  Number of subjects Score CFB Number of subjects Score CFB Number of subjects Score CFB
MCI (non-enriched)
 Baseline/screen 382 8.23 ± 3.76   382 13.96 ± 6.17   382 15.23 ± 6.68  
 Month 6 376 8.30 ± 4.14 0.01 ± 2.99 375 14.00 ± 6.68 −0.07 ± 4.01 375 15.28 ± 7.25 −0.07 ± 4.37
 Month 12 381 8.09 ± 4.42 −0.15 ± 3.09 380 13.72 ± 7.09 −0.23 ± 3.95 379 14.97 ± 7.83 −0.24 ± 4.49
 Month 24 382 8.94 ± 5.23 0.71 ± 3.56 382 15.09 ± 8.30 1.13 ± 4.87 382 16.57 ± 9.41 1.34 ± 5.68
 Month 36 169 9.02 ± 5.34 1.23 ± 4.00 168 15.11 ± 8.58 1.95 ± 5.58 168 16.89 ± 10.18 2.59 ± 6.89
MCI+ (enriched)
 Baseline/screen 206 9.43 ± 3.92   206 16.12 ± 6.28   206 17.52 ± 6.81  
 Month 6 204 9.71 ± 4.28 0.23 ± 3.17 203 16.38 ± 6.75 0.14 ± 4.18 203 17.84 ± 7.22 0.19 ± 4.56
 Month 12 206 9.57 ± 4.63 0.14 ± 3.43 205 16.24 ± 7.21 0.16 ± 4.10 205 17.75 ± 8.01 0.28 ± 4.69
 Month 24 206 10.91 ± 5.42 1.48 ± 3.78 206 18.32 ± 8.49 2.21 ± 5.20 206 20.15 ± 9.85 2.63 ± 6.24
 Month 36 89 11.37 ± 5.72 2.55 ± 4.40 89 18.96 ± 9.00 3.82 ± 6.03 89 21.42 ± 11.01 5.02 ± 7.60
MCI− (biomarker − negative)
 Baseline/screen 176 6.82 ± 3.02   176 17.52 ± 6.81   176 12.55 ± 5.43  
 Month 6 172 6.62 ± 3.25 −0.24 ± 2.75 172 17.84 ± 7.22 −0.31 ± 3.79 172 12.26 ± 6.03 −0.38 ± 4.12
 Month 12 175 6.35 ± 3.45 −0.50 ± 2.69 175 17.75 ± 8.01 −0.68 ± 3.73 174 11.69 ± 6.20 −0.85 ± 4.18
 Month 24 176 6.63 ± 3.88 −0.19 ± 3.06 176 20.15 ± 9.85 −0.11 ± 4.12 176 12.37 ± 6.80 −0.18 ± 4.51
 Month 36 80 6.40 ± 3.35 −0.25 ± 2.88 79 21.42 ± 11.01 −0.16 ± 4.15 79 11.78 ± 5.95 −0.15 ± 4.69
  1. ADAS-Cog Alzheimer’s Disease Assessment Scale–Cognitive subscale, CFB change from baseline, MCI mild cognitive impairment
  2. Data are presented as mean ± standard deviation. Increased score on ADAS-Cog indicates cognitive worsening