Alzheimer's Research & Therapy

Table 2 ADAS-Cog 11 scores at each visit and change from baseline for MCI patients

From: Alzheimer’s Disease Assessment Scale–Cognitive subscale variants in mild cognitive impairment and mild Alzheimer’s disease: change over time and the effect of enrichment strategies

	MCI (non-enriched)			MCI+ (enriched)			MCI− (‘biomarker-negative’)
	Number of subjects	ADAS-Cog 11	CFB	Number of subjects	ADAS-Cog 11	CFB	Number of subjects	ADAS-Cog 11	CFB
Baseline/screen	382	9.5 ± 4.29		206	10.83 ± 4.46		176	7.94 ± 3.49
Month 6	376	9.6 ± 4.75	0.0 ± 3.40	204	11.16 ± 4.82	0.3 ± 3.61	172	7.70 ± 3.91	−0.31 ± 3.10
Month 12	380	9.3 ± 5.23	−0.2 ± 3.68	206	11.08 ± 5.54	0.3 ± 4.06	174	7.27 ± 3.95	−0.68 ± 3.10
Month 24	382	10.4 ± 6.40	0.9 ± 4.45	206	12.74 ± 6.87	1.9 ± 4.92	176	7.70 ± 4.48	−0.24 ± 3.51
Month 36	169	10.8 ± 7.06	1.9 ± 5.45	89	13.83 ± 7.86	3.7 ± 6.21	80	7.40 ± 3.90	−0.26 ± 3.41

ADAS-Cog Alzheimer’s Disease Assessment Scale–Cognitive subscale, CFB change from baseline, MCI mild cognitive impairment
Increased score on ADAS-Cog 11 (maximum total score 70) indicates cognitive worsening. Data are presented as mean ± SD

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ISSN: 1758-9193

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