Table 2 Representative top 30 upstream regulators of genes differentially expressed between glutamate and glutamate + candesartan
Upstream regulator | Molecule type | p value of overlap |
|---|---|---|
Tumor necrosis factor | Cytokine | 1.06E-74 |
Lipopolysaccharide | Chemical drug | 3.26E-63 |
Interleukin-1beta | Cytokine | 1.02E-61 |
Interferon gamma | Cytokine | 4.75E-61 |
Transforming growth factor beta-1 | Growth factor | 1.99E-49 |
Nuclear factor kappa B (complex) | Complex | 1.80E-43 |
Dexamethasone | Chemical drug | 2.74E-42 |
Interleukin-6 | Cytokine | 2.16E-40 |
Colony Stimulating Factor 2 (CSF2) | Cytokine | 1.57E-39 |
Interleukin-10 | Cytokine | 6.06E-39 |
Of Kappa Light Polypeptide Gene Cin B Cells (IKBKB) | Kinase | 7.92E-39 |
Interleukin-13 | Cytokine | 1.46E-38 |
Poly rI:rC-RNA | Chemical reagent | 4.53E-38 |
Signal transducer and activator of transcription 3 (STAT3) | Transcription regulator | 1.80E-37 |
Amyloid precursor protein | Other | 2.86E-37 |
Nuclear Factor Of Kappa Light Polypeptide Gene Enhancer in B Cell Inhibitor, Alpha (NFKBIA) | Transcription regulator | 4.57E-36 |
Myeloid differentiation primary response gene 88 (MYD88) | Other | 4.97E-36 |
Tretinoin | Chemical—endogenous mammalian | 6.44E-36 |
E. coli B4 lipopolysaccharide | Chemical toxicant | 1.36E-35 |
PD98059 | Chemical—kinase inhibitor | 1.85E-35 |
Beta-estradiol | Chemical—endogenous mammalian | 9.64E-35 |
Interleukin-4 | Cytokine | 1.46E-34 |
Apolipoprotein E | Transporter | 2.32E-33 |
Platelet-derived growth factor BB | Complex | 2.99E-33 |
Conserved Helix -Loop Helix Ubiquitous Kinase (CHUK) | Kinase | 6.05E-33 |
Toll-like receptor 4 | Transmembrane receptor | 2.55E-32 |
Angiotensinogen (AGT) | Growth factor | 3.51E-32 |
Phorbol myristate acetate | Chemical drug | 6.73E-32 |
SB203580 | Chemical—kinase inhibitor | 1.17E-31 |
Tumor necrosis factor superfamily member 11 (TNFSF11) | Cytokine | 1.79E-31 |