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Table 5 Executive function, working memory and planning test

From: Cognitive impact after short-term exposure to different proton pump inhibitors: assessment using CANTAB software

Spatial Working Memory (SWM)
Drug Name of task Mean ± SEM p1 value 95 % CI-D (Lower, Upper) Cohen’s d for p1 Value p2 Value 95 % CI-D (Lower, Upper) Cohen’s d for p2 Value
Baseline After 7 Days
OME SWM BE 15.800 ± 3.123 29.500 ± 4.465 0.002** −21.794, -5.606 2.553ǂ 0.111 −6.717, 26.917 0.595
SWM Strategy 32.500 ± 0.703 34.900 ± 0.924 0.012* −4.401, -0.399 1.809ǂ 0.385 −4.038, 3.038 0.140
LAN SWM BE 29.100 ± 5.664 34.900 ± 6.781 0.153 −17.906, 6.306 0.723 0.060 −4.444, 35.444 0.769
SWM Strategy 34.700 ± 0.895 37.700 ± 0.967 0.001*** −4.720, -1.280 2.631ǂ 0.097 −1.288, 5.888 0.635
RAB SWM BE 22.500 ± 5.119 32.200 ± 7.360 0.016* −18.429, -0.971 1.676ǂ 0.106 −8.031, 33.631 0.608
SWM Strategy 34.100 ± 1.215 36.500 ± 1.607 0.022* −4.717, -0.083 1.562ǂ 0.306 −3.389, 5.589 0.243
PAN SWM BE 21.600 ± 4.766 31.500 ± 6.114 0.095 −25.730, 5.930 0.943ǂ 0.098 −6.869, 31.069 0.632
SWM Strategy 33.400 ± 1.056 36.100 ± 1.027 0.010** −4.861, -0.539 1.885ǂ 0.346 −2.961, 4.361 0.189
ESO SWM BE 24.900 ± 4.451 28.800 ± 6.141 0.244 −16.126, 8.326 0.481 0.165 −9.606, 28.406 0.489
SWM Strategy 33.500 ± 0.719 35.200 ± 0.940 0.035* −3.579, 0.179 1.365ǂ 0.453 −3.757, 3.357 0.055
CON SWM BE 19.400 ± 4.492 19.400 ± 6.644 0.500 −11.406, 11.406 N/A
SWM Strategy 34.400 ± 1.046 35.400 ± 1.408 0.118 −2.784, 0.784 N/A
  1. Values are expressed as mean ± SEM (n=10), BE=Between Errors, 95 % CI-D=95 % Confidence Interval of the Difference (lower, upper), p1= p value found after Paired-Samples t-test within volunteers (five test groups) before and after consuming drugs and placebo (one control group) respectively with degree of freedom (df)=9; p2= p value found after Independent-Samples t-test between each five test groups with control group having degree of freedom (df)=18. *, ** and *** indicate statistically significant at alpha (<0.05), (<0.01) & (<0.001) respectively. ǂ indicates large effect size in Cohen’s d value
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