Cognitive impact after short-term exposure to different proton pump inhibitors: assessment using CANTAB software

Table 4 Attention test (visual sustained attention)

Rapid Visual Information Processing (RVP)
Drug	Name of task	Mean ± SEM		p1 value	95 % CI-D (Lower, Upper)	Cohen’s d for p1 Value	p2 Value	95 % CI-D (Lower, Upper)	Cohen’s d for p2 Value
Drug	Name of task	Baseline	After 7 Days	p1 value	95 % CI-D (Lower, Upper)	Cohen’s d for p1 Value	p2 Value	95 % CI-D (Lower, Upper)	Cohen’s d for p2 Value
OME	RVP A'	0.940 ± 0.014	0.920 ± 0.015	0.030*	−0.001, 0.050	1.428^ǂ	0.492	−0.045, 0.044	0.009 (S)
LAN	RVP A'	0.920 ± 0.013	0.900 ± 0.009	0.043*	−0.004, 0.044	1.281^ǂ	0.251	−0.049, 0.025	0.322 (S)
RAB	RVP A'	0.934 ± 0.013	0.900 ± 0.016	0.037*	−0.004, 0.072	1.343^ǂ	0.248	−0.062, 0.031	0.327 (S)
PAN	RVP A'	0.931 ± 0.010	0.900 ± 0.016	0.029*	−0.001, 0.063	1.445^ǂ	0.248	−0.063, 0.031	0.328 (S)
ESO	RVP A'	0.940 ± 0.016	0.918 ± 0.010	0.032*	−0.002, 0.046	1.398^ǂ	0.441	−0.035, 0.040	0.071 (S)
CON	RVP A'	0.901 ± 0.013	0.915 ± 0.015	0.217	−0.054, 0.025	N/A

Values are expressed as mean ± SEM (n=10), 95 % CI-D=95 % Confidence Interval of the Difference (lower, upper), p1= p value found after Paired-Samples t-test within volunteers (five test groups) before and after consuming drugs and placebo (one control group) respectively with degree of freedom (df)=9; p2= p value found after Independent-Samples t-test between each five test groups with control group having degree of freedom (df)=18 . * indicates statistically significant at alpha (<0.05). ^ǂ indicates large effect size in Cohen’s d value

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