Alzheimer's Research & Therapy

Table 1 Screening or familiarization test

From: Cognitive impact after short-term exposure to different proton pump inhibitors: assessment using CANTAB software

Motor Screening Test (MOT)
Drug	Name of task	Mean ± SEM		p1 value	95 % CI-D (Lower, Upper)	Cohen’s d for p1 Value	p2 Value	95 % CI-D (Lower, Upper)	Cohen’s d for p2 Value
Drug	Name of task	Baseline	After 7 Days	p1 value	95 % CI-D (Lower, Upper)	Cohen’s d for p1 Value	p2 Value	95 % CI-D (Lower, Upper)	Cohen’s d for p2 Value
OME	MOT M latency	784.300 ± 48.095	849.200 ± 80.201	0.206	−235.741, 105.941	0.573	0.292	−143.601, 244.661	0.305
OME	MOT M error	7.400 ± 0.427	9.600 ± 1.166	0.038*	−4.696, 0.296	1.329^ǂ	0.187	−1.577, 3.997	0.429
LAN	MOT M latency	744.400 ± 24.413	865.700 ± 58.618	0.014*	−226.980, -15.620	1.731^ǂ	0.181	−83.723, 217.563	0.439
LAN	MOT M error	8.600 ± 0.686	9.600 ± 0.968	0.171	−3.262, 1.262	0.667	0.101	−0.885, 3.813	0.702
RAB	MOT M latency	890.000 ± 53.938	883.900 ± 48.187	0.470	−171.647, 184.847	0.051	0.098	−48.222, 218.502	0.632
RAB	MOT M error	7.000 ± 0.615	8.500 ± 1.276	0.166	−4.808, 1.808	0.684	0.451	−2.849, 3.198	0.071
PAN	MOT M latency	768.100 ± 40.731	847.900 ± 36.554	0.009**	−143.281, -16.319	1.896^ǂ	0.191	−66.545, 165.045	0.421
PAN	MOT M error	9.700 ± 0.870	9.900 ± 0.767	0.405	−2.041, 1.641	0.164	0.045*	−0.283, 3.537	0.843^ǂ
ESO	MOT M latency	696.300 ± 52.443	788.700 ± 60.783	0.096	−241.107, 56.307	0.937^ǂ	0.446	−164.470,144.343	0.065
ESO	MOT M error	9.100 ± 0.722	10.300 ± 0.597	0.044*	−2.623, 0.223	1.272^ǂ	0.010**	0.352, 3.748	1.196^ǂ
CON	MOT M latency	853.700±53.702	798.700 ± 41.260	0.088	−29.868, 139.868	N/A
CON	MOT M error	9.500 ± 0.687	8.300 ± 0.539	0.073	−0.513, 2.913	N/A

Values are expressed as mean ± SEM (n=10), M=Mean, 95 % CI-D=95 % Confidence Interval of the Difference (lower, upper), p1= p value found after Paired-Samples t-test within volunteers (five test groups) before and after consuming drugs and placebo (one control group) respectively with degree of freedom (df)=9; p2 = p value found after Independent-Samples t-test between each five test groups with control group having degree of freedom (df)=18. * and ** indicate statistically significant at alpha (<0.05) & (<0.01) respectively. ^ǂ indicates large effect size in Cohen’s d value

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ISSN: 1758-9193

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