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Table 1 Screening or familiarization test

From: Cognitive impact after short-term exposure to different proton pump inhibitors: assessment using CANTAB software

Motor Screening Test (MOT)
Drug Name of task Mean ± SEM p1 value 95 % CI-D (Lower, Upper) Cohen’s d for p1 Value p2 Value 95 % CI-D (Lower, Upper) Cohen’s d for p2 Value
Baseline After 7 Days
OME MOT M latency 784.300 ± 48.095 849.200 ± 80.201 0.206 −235.741, 105.941 0.573 0.292 −143.601, 244.661 0.305
MOT M error 7.400 ± 0.427 9.600 ± 1.166 0.038* −4.696, 0.296 1.329ǂ 0.187 −1.577, 3.997 0.429
LAN MOT M latency 744.400 ± 24.413 865.700 ± 58.618 0.014* −226.980, -15.620 1.731ǂ 0.181 −83.723, 217.563 0.439
MOT M error 8.600 ± 0.686 9.600 ± 0.968 0.171 −3.262, 1.262 0.667 0.101 −0.885, 3.813 0.702
RAB MOT M latency 890.000 ± 53.938 883.900 ± 48.187 0.470 −171.647, 184.847 0.051 0.098 −48.222, 218.502 0.632
MOT M error 7.000 ± 0.615 8.500 ± 1.276 0.166 −4.808, 1.808 0.684 0.451 −2.849, 3.198 0.071
PAN MOT M latency 768.100 ± 40.731 847.900 ± 36.554 0.009** −143.281, -16.319 1.896ǂ 0.191 −66.545, 165.045 0.421
MOT M error 9.700 ± 0.870 9.900 ± 0.767 0.405 −2.041, 1.641 0.164 0.045* −0.283, 3.537 0.843ǂ
ESO MOT M latency 696.300 ± 52.443 788.700 ± 60.783 0.096 −241.107, 56.307 0.937ǂ 0.446 −164.470,144.343 0.065
MOT M error 9.100 ± 0.722 10.300 ± 0.597 0.044* −2.623, 0.223 1.272ǂ 0.010** 0.352, 3.748 1.196ǂ
CON MOT M latency 853.700±53.702 798.700 ± 41.260 0.088 −29.868, 139.868 N/A
MOT M error 9.500 ± 0.687 8.300 ± 0.539 0.073 −0.513, 2.913 N/A
  1. Values are expressed as mean ± SEM (n=10), M=Mean, 95 % CI-D=95 % Confidence Interval of the Difference (lower, upper), p1= p value found after Paired-Samples t-test within volunteers (five test groups) before and after consuming drugs and placebo (one control group) respectively with degree of freedom (df)=9; p2 = p value found after Independent-Samples t-test between each five test groups with control group having degree of freedom (df)=18. * and ** indicate statistically significant at alpha (<0.05) & (<0.01) respectively. ǂ indicates large effect size in Cohen’s d value