APLP1 as a cerebrospinal fluid biomarker for γ-secretase modulator treatment

Table 2 Tandem mass spectrometric identification of APLP1 peptides

Peptide	Observed m/z	ppm	Ion score	Expect	a/b/y ions
APLP1β14	1372.71	30.4	48	1.6x10^-5	–/4/6
APLP1β17	1615.83	23.7	79	1.3x10^-8	4/6/11
APLP1β18	1728.91	21.9	65	3.0x10^-7	–/8/10
APLP1β19	1842.06	56.7	18	1.7x10^-2	–/5/4
APLP1β21	2086.19	48.1	24	3.9x10^-3	–/6/–
APLP1β23	2214.14	−2.91	15	3.3x10^-2	–/4/–
APLP1β25	2328.51	138	79	1.3x10^-8	7/6/11
APLP1β27	2472.31	27.8	100	9.4x10^-11	9/5/9
APLP1β28	2585.40	28.3	93	5.3x10^-10	9/11/10

The Table shows the peptides that were identified by tandem mass spectrometry. The acquired fragment mass spectra were used for searching an in-house Mascot Deamon server containing a designated amyloid-like protein 1 (APLP1) database. Also shown are the observed masses and the deviation from the theoretical masses in ppm, as well as identification statistics given as the Mascot Ion Score and Expect value. The number of identified a, b and y ions are also indicated

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