Skip to main content

Table 1 APLP1 precursor ion identification in full mass spectrum

From: APLP1 as a cerebrospinal fluid biomarker for γ-secretase modulator treatment

Sequence Theoretical mass (Da) Observed mass (Da) dogs ppm dogs Observed mass (Da) human ppm human Annotation
DELAPAGTGVSRE 1300.63 1300.60 −172 1300.63 39 APLP1β13
DELAPAGTGVSREA 1371.66 1371.65 −114 1371.67 20 APLP1β14
DELAPAGTGVSREAVSG 1614.78 1614.78 −8.5 1614.78 −0.058 APLP1β17
DELAPAGTGVSREAVSGL 1727.87 1727.87 13 1727.87 0.12 APLP1β18
DELAPAGTGVSREAVSGLL 1840.95 1840.96 12 1840.95 −8.2 APLP1β19
DELAPAGTGVSREAVSGLLI 1954.04 1954.04 8.5 1954.04 −8.5 APLP1β20
DELAPAGTGVSREAVSGLLIM 2085.08 2085.08 −2.4 2085.08 1.1 APLP1β21
DELAPAGTGVSREAVSGLLIMG 2142.10 2142.10 −7.6 2142.10 −0.46 APLP1β22
DELAPAGTGVSREAVSGLLIMGA 2213.14 2213.13 −13 APLP1β23
DELAPAGTGVSREAVSGLLIMGAG 2270.16 2270.16 8.5 APLP1β24
DELAPAGTGVSREAVSGLLIMGAGG 2327.18 2327.18 3.3 2327.18 1.0 APLP1β25
DELAPAGTGVSREAVSGLLIMGAGGG 2384.20 2384.19 −33 2384.19 −65 APLP1β26
DELAPAGTGVSREAVSGLLIMGAGGGS 2471.23 2471.23 −0.53 2471.23 −0.91 APLP1β27
DELAPAGTGVSREAVSGLLIMGAGGGSL 2584.32 2584.32 0.72 2584.32 0.31 APLP1β28
  1. Full mass spectra of amyloid-like protein 1 (APLP1) immunoprecipitated from dog and human cerebrospinal fluid were acquired by MALDI-TOF/TOF. The Table shows the amino acid sequences, the observed masses in Da in dogs and human and their deviation from the theoretical peptide mass in ppm for the peptides identified