Fig. 1

In vivo μPET quantification of (a) [18F]FDG, (b) [11C]PiB, and (c) [18F]AV45 uptake in WT and APPPS1-21 mice using VOI analysis. Data are expressed as mean + standard deviation, unpaired Student t-test **** p < 0.0001, ***p < 0.001, **p < 0.01, *p < 0.05 (Holm-Sidak correction for multiple comparisons). μPET micro-positron emission tomography, FDG fluorodeoxyglucose, PiB Pittsburgh compound B, WT wild type, VOI volume of interest