Role of ABCA7 loss-of-function variant in Alzheimer's disease: a replication study in European–Americans

Table 1 Association of ABCA7 variants with Alzheimer’s disease in studied groups based on Fisher’s association test, including age, gender, and PC as covariates. Gene-based analysis was conducted with CMC collapsing method

rsID/position^a	MAF		OR	P
rsID/position^a	Cases	Controls	(95 % CI)	P
rs4147929	0.179	0.1581	1.162	0.022
(GWAS SNP)	0.179	0.1581	(1.02–1.31)	0.022
19:998507^a	0.006	0.0037	1.735	0.121
p.Glu709AlafsX86	0.006	0.0037	(0.54–3.04)	0.121
19:1006907^a	0.003	0.0027	1.285	0.569
p.Leu1403ArgfsX7	0.003	0.0027	(0.76–3.21)	0.569
rs113809142	0.002	0.0012	1.695	0.451
c.4416+2T>G	0.002	0.0012	(0.34–5.91)	0.451
rs200538373	0.009	0.0076	1.231	0.476
c.5570+5G>C	0.009	0.0076	(0.68–2.61)	0.476
Loss-of-function	0.016	0.0107	1.549	0.038
(All low frequency variants)	0.016	0.0107	(1.02–2.34)	0.038

^aNCBI Build 36
MAF
Values shown in bold are significant at the P < 0.05 level
CI Confidence interval, CMC Combined multivariate and collapsing, GWAS Genome-wide association study, MAF Minor allele frequency, OR Odds ratio, PC Principal component factors, SNP Single Nucleotide Polymorphism

ISSN: 1758-9193