Skip to main content

Table 1 Association of ABCA7 variants with Alzheimer’s disease in studied groups based on Fisher’s association test, including age, gender, and PC as covariates. Gene-based analysis was conducted with CMC collapsing method

From: Role of ABCA7 loss-of-function variant in Alzheimer's disease: a replication study in European–Americans

rsID/positiona MAF OR P
Cases Controls (95 % CI)
rs4147929 0.179 0.1581 1.162 0.022
(GWAS SNP) (1.02–1.31)
19:998507a 0.006 0.0037 1.735 0.121
p.Glu709AlafsX86 (0.543.04)
19:1006907a 0.003 0.0027 1.285 0.569
p.Leu1403ArgfsX7 (0.763.21)
rs113809142 0.002 0.0012 1.695 0.451
c.4416+2T>G (0.345.91)
rs200538373 0.009 0.0076 1.231 0.476
c.5570+5G>C (0.682.61)
Loss-of-function 0.016 0.0107 1.549 0.038
(All low frequency variants) (1.02–2.34)
  1. aNCBI Build 36
  2. MAF
  3. Values shown in bold are significant at the P < 0.05 level
  4. CI Confidence interval, CMC Combined multivariate and collapsing, GWAS Genome-wide association study, MAF Minor allele frequency, OR Odds ratio, PC Principal component factors, SNP Single Nucleotide Polymorphism