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Table 3 Variables predicting AD in addition to < −2 SD on one episodic memory test

From: Predicting Alzheimer's disease development: a comparison of cognitive criteria and associated neuroimaging biomarkers

   Block by block Final model
Predictor Nagelkerke’s R 2 Odds ratio Confidence interval p Odds ratio Confidence interval p
Block 1: main predictors .380       
Age   1.017 1.0, 1.1 0.403 0.992 0.9, 1.0 0.735
Education   0.981 0.9, 1.1 0.668 0.992 0.9, 1.1 0.877
Sex   0.843 0.5, 1.4 0.528 0.868 0.5, 1.6 0.639
Mini-mental state exam   0.672 0.6, 0.8 <0.001 0.756 0.6, 0.9 0.001
< −2 SD on one test   7.652 4.4, 13.3 <0.001 4.722 2.6, 8.7 <0.001
Block 2: non-memory tests .416       
Category fluency   0.850 0.7, 1.1 0.211 0.859 0.7, 1.1 0.268
Boston naming test   0.923 0.9, 1.0 0.052 0.925 0.9, 1.0 0.071
Trails B/A ratio   1.367 1.1, 1.8 0.017 1.275 1.0, 1.7 0.089
Block 3: biomarkers .469       
Apolipoprotein E ε4        0.035
Apolipoprotein E ε4 (1 allele)      1.748 1.0, 3.1 0.060
Apolipoprotein E ε4 (2 alleles)      2.910 1.2, 7.1 0.019
Total hippocampal volume      0.018 0.0, 2.7 0.115
Brain parenchymal fraction      0.000 0.0, 4.7 0.078
White matter hyperintensity      1.029 0.9, 1.1 0.609
Ventricular cerebrospinal fluid      1.098 0.9, 1.4 0.382