Table 3 Variables predicting AD in addition to < −2 SD on one episodic memory test
Block by block | Final model | ||||||
|---|---|---|---|---|---|---|---|
Predictor | Nagelkerke’s R 2 | Odds ratio | Confidence interval | p | Odds ratio | Confidence interval | p |
Block 1: main predictors | .380 | ||||||
Age | 1.017 | 1.0, 1.1 | 0.403 | 0.992 | 0.9, 1.0 | 0.735 | |
Education | 0.981 | 0.9, 1.1 | 0.668 | 0.992 | 0.9, 1.1 | 0.877 | |
Sex | 0.843 | 0.5, 1.4 | 0.528 | 0.868 | 0.5, 1.6 | 0.639 | |
Mini-mental state exam | 0.672 | 0.6, 0.8 | <0.001 | 0.756 | 0.6, 0.9 | 0.001 | |
< −2 SD on one test | 7.652 | 4.4, 13.3 | <0.001 | 4.722 | 2.6, 8.7 | <0.001 | |
Block 2: non-memory tests | .416 | ||||||
Category fluency | 0.850 | 0.7, 1.1 | 0.211 | 0.859 | 0.7, 1.1 | 0.268 | |
Boston naming test | 0.923 | 0.9, 1.0 | 0.052 | 0.925 | 0.9, 1.0 | 0.071 | |
Trails B/A ratio | 1.367 | 1.1, 1.8 | 0.017 | 1.275 | 1.0, 1.7 | 0.089 | |
Block 3: biomarkers | .469 | ||||||
Apolipoprotein E ε4 | 0.035 | ||||||
Apolipoprotein E ε4 (1 allele) | 1.748 | 1.0, 3.1 | 0.060 | ||||
Apolipoprotein E ε4 (2 alleles) | 2.910 | 1.2, 7.1 | 0.019 | ||||
Total hippocampal volume | 0.018 | 0.0, 2.7 | 0.115 | ||||
Brain parenchymal fraction | 0.000 | 0.0, 4.7 | 0.078 | ||||
White matter hyperintensity | 1.029 | 0.9, 1.1 | 0.609 | ||||
Ventricular cerebrospinal fluid | 1.098 | 0.9, 1.4 | 0.382 | ||||